氨甲蝶呤和氟脱氧尿苷对禽成髓细胞瘤病毒繁殖的短暂抑制作用。
Transient inhibition of avian myeloblastosis virus reproduction by amethopterin and fluorodeoxyuridine.
作者信息
Knudson A G, Brodetsky A M, Baluda M A
出版信息
J Virol. 1967 Dec;1(6):1150-7. doi: 10.1128/JVI.1.6.1150-1157.1967.
Abstract
Avian myeloblastosis virus cannot initiate its reproduction in the presence of amethopterin or fluorodeoxyuridine. This inhibition is reversed by thymidine. Addition of either inhibitor after virus production has started does not inhibit further virus synthesis. In presence of either inhibitor, deoxyribonucleic acid synthesis is inhibited by over 90%, but ribonucleic acid synthesis is not affected. Cells resume their normal growth rate 24 hr after removal of either inhibitor.
摘要
禽成髓细胞瘤病毒在氨甲蝶呤或氟脱氧尿苷存在的情况下无法开始其繁殖。这种抑制作用可被胸腺嘧啶核苷逆转。在病毒产生开始后添加任何一种抑制剂都不会抑制进一步的病毒合成。在任何一种抑制剂存在的情况下，脱氧核糖核酸合成被抑制超过90%，但核糖核酸合成不受影响。去除任何一种抑制剂24小时后，细胞恢复其正常生长速度。
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