Tanna V L, Go R C, Winokur G, Elston R C
Neuropsychobiology. 1979;5(2):102-13. doi: 10.1159/000117670.
Depression spectrum disease is an unipolar depressive illness in which at least one member of the family has unipolar depression and at least one other first degree relative has alcoholism and/or antisocial personality; using this definition, 14 depression spectrum disease families are studied. Assuming, among other things, that variability in age of onset is environmentally caused and lognormally distributed, segregation analysis shows that the data are compatible with the dichotomy of 'affected' versus 'not affected' being due to an autosomal dominant gene. A simple environmental hypothesis in which the transmission of the illness does not depend upon the parents' type could be rejected (p less than 0.001). Linkage analysis is performed by the method of maximum likelihood, taking the best fitting Mendelian model found in the segregation analysis. The results show virtually no evidence of linkage between depression spectrum disease and C3, but suggestive evidence (lod score = 1.03) of linkage between depression spectrum disease and alpha-haptoglobin (both these linkages were previously suggested by significant results in sib-pair analyses).
抑郁谱系障碍是一种单相抑郁性疾病，其中家族中至少有一名成员患有单相抑郁症，且至少有另一名一级亲属患有酒精中毒和/或反社会人格障碍；采用这一定义，对14个抑郁谱系障碍家族进行了研究。除其他因素外，假设发病年龄的变异性是由环境引起的且呈对数正态分布，分离分析表明，数据与常染色体显性基因导致的“患病”与“未患病”二分法相符。一种简单的环境假说，即疾病的传播不取决于父母的类型，被拒绝（p小于0.001）。连锁分析采用最大似然法进行，采用在分离分析中找到的最佳拟合孟德尔模型。结果显示，几乎没有证据表明抑郁谱系障碍与C3之间存在连锁，但有提示性证据（lod分数 = 1.03）表明抑郁谱系障碍与α-触珠蛋白之间存在连锁（这两种连锁先前在同胞对分析的显著结果中已被提出）。
