在18个家族中排除了c-Harvey-ras-1和胰岛素基因座（INS）DNA标记与单相抑郁症及酗酒的连锁关系。

Linkage of c-Harvey-ras-1 and INS DNA markers to unipolar depression and alcoholism is ruled out in 18 families.

作者信息

Wesner R B, Tanna V L, Palmer P J, Goedken R J, Crowe R R, Winokur G

机构信息

Department of Psychiatry, University of Iowa College of Medicine, Iowa City.

出版信息

Eur Arch Psychiatry Neurol Sci. 1990;239(6):356-60. doi: 10.1007/BF01734541.

DOI:10.1007/BF01734541

PMID:2144234

Abstract

Eighteen families informative for c-Harvey-ras-1 and INS DNA markers were tested for linkage to unipolar depression and alcoholism. No evidence of linkage was found between these DNA markers and the disorders observed in the families. This study fails to replicate the Old Order Amish Study and suggests that a significant degree of genetic heterogeneity may be present among psychiatric disorders.

摘要

对18个携带c-Harvey-ras-1和胰岛素基因座（INS）DNA标记的信息家系进行了单极抑郁症和酒精中毒的连锁分析。在这些DNA标记与家系中观察到的疾病之间未发现连锁证据。本研究未能重复老派阿米什人研究的结果，并提示精神疾病之间可能存在显著程度的遗传异质性。