Fãnanás L, Moral P, Gutiérrez B, Guillamat R, Vallés V, Campillo M, Gutiérrez-Pacheco B, Lütken N, Bertranpetit J
Laboratori d'Antropologia, Facultat de Biologia, Universitat de Barcelona, Spain.
Hum Hered. 1997 Jan-Feb;47(1):27-32. doi: 10.1159/000154385.
Several studies have shown that major depression is accompanied by significantly increased plasma levels of positive acute-phase proteins such as haptoglobin (Hp). A significant higher frequency of the HP1 allele has recently been detected in patients with unipolar major depression. Pursuing the hypothesis that certain unipolar and bipolar disorders may be genetically related, this study analyzed Hp genotype and allele frequencies in bipolar patients, taking into account their family history of major affective disorders. An increase of HP1 allele frequency was found in the subgroup of patients with family history of exclusively unipolar disorder (70% in patients vs. 38% in controls, chi2 = 8.34, p = 0.004). The relative risk for the HP*1 carriers in this subgroup was 3.8 (chi2 = 7.29, p = 0.007). These results suggest a genetic and etiological heterogeneity in the bipolar disorder.
多项研究表明，重度抑郁症伴有血浆中诸如触珠蛋白（Hp）等阳性急性期蛋白水平显著升高。最近在单相重度抑郁症患者中检测到HP1等位基因的频率显著更高。基于某些单相和双相情感障碍可能存在遗传关联这一假设，本研究分析了双相情感障碍患者的Hp基因型和等位基因频率，并考虑了他们的重性情感障碍家族史。在仅有单相情感障碍家族史的患者亚组中发现HP1等位基因频率增加（患者为70%，对照组为38%，χ2 = 8.34，p = 0.004）。该亚组中HP*1携带者的相对风险为3.8（χ2 = 7.29，p = 0.007）。这些结果提示双相情感障碍存在遗传和病因学异质性。
