Br Med J. 1969 Nov 8;4(5679):329-33.
In a large survey of the efficacy of pertussis vaccines made in 33 areas in the United Kingdom during the period 1 November 1966 to 31 October 1967 a total of 3,564 households were investigated. Nine hundred and seventy-seven strains of Bordetella pertussis and 6 strains of Bord. parapertussis were isolated from persons in 792 households.After contact in the home 56% of fully vaccinated children under 5 years of age developed a paroxysmal cough, and in more than two-thirds of these patients the diagnosis was confirmed bacteriologically. This suggests that pertussis vaccination was not very effective. A comparison with the attack rate in unvaccinated children also indicates a poor protection from vaccination.NONE OF THE FOLLOWING FACTORS APPEARED TO BE RESPONSIBLE FOR THE POOR PROTECTION AFFORDED BY VACCINATION: vaccination in early infancy, a long interval since vaccination, and the absence of booster doses.Almost all the children in the survey had been given vaccines from a single manufacturer, and therefore a comparison of the efficacy of vaccines prepared by different manufacturers was inconclusive. All the vaccinated children in the survey had been vaccinated before or during 1967. The efficacy of current preparations will require to be assessed by continuing surveillance.
在1966年11月1日至1967年10月31日期间，对英国33个地区的百日咳疫苗效力进行的一项大型调查中，共调查了3564户家庭。从792户家庭的人员中分离出977株百日咳博德特氏菌和6株副百日咳博德特氏菌。在家庭接触后，56%的5岁以下完全接种疫苗的儿童出现阵发性咳嗽，其中超过三分之二的患者经细菌学确诊。这表明百日咳疫苗效果不太理想。与未接种疫苗儿童的发病率进行比较也表明疫苗提供的保护作用较差。以下因素均未显示与疫苗提供的保护作用不佳有关：婴儿早期接种、接种后间隔时间长以及未接种加强剂。调查中的几乎所有儿童都接种了单一制造商生产的疫苗，因此不同制造商生产的疫苗效力比较尚无定论。调查中所有接种疫苗的儿童均在1967年之前或期间接种。当前制剂的效力需要通过持续监测来评估。
