Stone T W, Taylor D A
Neurosci Lett. 1979 Jan;11(1):93-7. doi: 10.1016/0304-3940(79)90062-4.
Adenosine and AMP (5'-adenosine monophosphate) applied by microiontophoresis produced depression of neuronal firing rates in cerebral cortex. A number of antidepressant drugs including examples which are known not to affect noradrenaline uptake systems, potentiated the depressant purine effects. Noradrenaline responses were unaffected or reduced. Purines may therefore be important in the mechanism of action of antidepressant drugs.
通过微离子电泳施加的腺苷和AMP（5'-腺苷一磷酸）可降低大脑皮层神经元的放电频率。许多抗抑郁药物，包括已知不影响去甲肾上腺素摄取系统的药物，都能增强嘌呤的抑制作用。去甲肾上腺素反应不受影响或减弱。因此，嘌呤可能在抗抑郁药物的作用机制中起重要作用。
