4-氨基吡啶对神经元对三磷酸腺苷抑制反应的阻断作用。
4-Aminopyridine blockade of neuronal depressant responses to adenosine triphosphate.
作者信息
Perkins M N, Stone T W
出版信息
Br J Pharmacol. 1980 Nov;70(3):425-8. doi: 10.1111/j.1476-5381.1980.tb08720.x.
Abstract
1 Adenosine, adenosine monophosphate and adenosine triphosphate (ATP) depressed the firing rate of neurones in the rat cerebral cortex when applied by microinontophoresis. 2 4-Aminopyridine, also applied iontophoretically blocked the depressant effects of the purines, without affecting responses to gamma-aminobutyric acid (GABA). This blockade was effected against purine depressions of both spontaneous and glutamate-evoked activity, suggesting that the interaction occurred postsynaptically.
摘要
- 当通过微量离子透入法施加时，腺苷、一磷酸腺苷和三磷酸腺苷（ATP）降低了大鼠大脑皮层神经元的放电频率。2. 同样通过离子透入法施加的4-氨基吡啶阻断了嘌呤的抑制作用，而不影响对γ-氨基丁酸（GABA）的反应。这种阻断作用针对嘌呤对自发活动和谷氨酸诱发活动的抑制，表明这种相互作用发生在突触后。
相似文献
1
4-Aminopyridine blockade of neuronal depressant responses to adenosine triphosphate.4-氨基吡啶对神经元对三磷酸腺苷抑制反应的阻断作用。
Br J Pharmacol. 1980 Nov;70(3):425-8. doi: 10.1111/j.1476-5381.1980.tb08720.x.
2
Antagonism by clonidine of neuronal depressant responses to adenosine, adenosine-5'-monophosphate and adenosine triphosphate.可乐定对神经元对腺苷、5'-单磷酸腺苷和三磷酸腺苷的抑制反应的拮抗作用。
Br J Pharmacol. 1978 Nov;64(3):369-74. doi: 10.1111/j.1476-5381.1978.tb08659.x.
3
Non-synaptic modulation of repetitive firing by adenosine is antagonized by 4-aminopyridine in a rat hippocampal slice.在大鼠海马切片中，4-氨基吡啶可拮抗腺苷对重复放电的非突触调节作用。
Neurosci Lett. 1986 Jun 30;67(3):334-8. doi: 10.1016/0304-3940(86)90332-0.
4
The effects of 4-aminopyridine on the isolated vas deferens and its effects on the inhibitory properties of adenosine, morphine, noradrenaline and gamma-aminobutyric acid.4-氨基吡啶对离体输精管的作用及其对腺苷、吗啡、去甲肾上腺素和γ-氨基丁酸抑制特性的影响。
Br J Pharmacol. 1981 Jul;73(3):791-6. doi: 10.1111/j.1476-5381.1981.tb16817.x.
5
Effects of ATP and AMP on hippocampal neurones of the rat in vitro.ATP和AMP对体外培养的大鼠海马神经元的影响。
Brain Res Bull. 1984 Jul;13(1):199-201. doi: 10.1016/0361-9230(84)90022-4.
6
Depression of the firing of rat cerebral cortical neurons by 2-azido analogues of adenine nucleotides.腺嘌呤核苷酸的2-叠氮类似物对大鼠大脑皮质神经元放电的抑制作用。
Neurosci Lett. 1981 Jan 1;21(1):63-6. doi: 10.1016/0304-3940(81)90058-6.
7
Purine-induced depression of dorsal horn neurons in the cat spinal cord: enhancement by tachykinins.嘌呤诱导猫脊髓背角神经元抑制：速激肽增强作用
Neuroscience. 1987 Dec;23(3):903-15. doi: 10.1016/0306-4522(87)90167-9.
8
Antidepressant drugs potentiate suppression by adenosine of neuronal firing in rat cerebral cortex.抗抑郁药物可增强腺苷对大鼠大脑皮层神经元放电的抑制作用。
Neurosci Lett. 1979 Jan;11(1):93-7. doi: 10.1016/0304-3940(79)90062-4.
9
Properties of adenosine-triphosphate-regulated potassium channels in guinea-pig ventricular cells.豚鼠心室肌细胞中三磷酸腺苷调节钾通道的特性
J Physiol. 1985 Jun;363:441-62. doi: 10.1113/jphysiol.1985.sp015721.
10
Effects of adenosine and adenine nucleotides on synaptic transmission in the cerebral cortex.腺苷和腺嘌呤核苷酸对大脑皮质突触传递的影响。
Can J Physiol Pharmacol. 1979 Nov;57(11):1289-312. doi: 10.1139/y79-194.
引用本文的文献
1
The effects of 4-aminopyridine on the isolated vas deferens and its effects on the inhibitory properties of adenosine, morphine, noradrenaline and gamma-aminobutyric acid.4-氨基吡啶对离体输精管的作用及其对腺苷、吗啡、去甲肾上腺素和γ-氨基丁酸抑制特性的影响。
Br J Pharmacol. 1981 Jul;73(3):791-6. doi: 10.1111/j.1476-5381.1981.tb16817.x.
2
Nicotinamide adenine dinucleotide depresses synaptic transmission in the hippocampus and has specific binding sites on the synaptic membranes.烟酰胺腺嘌呤二核苷酸抑制海马体中的突触传递，并在突触膜上具有特定的结合位点。
Br J Pharmacol. 1983 Jun;79(2):553-64. doi: 10.1111/j.1476-5381.1983.tb11030.x.
3
Inhibitory effect of adenosine on transmission in sympathetic ganglia.腺苷对交感神经节传递的抑制作用。
Naunyn Schmiedebergs Arch Pharmacol. 1984 Nov;328(1):16-9. doi: 10.1007/BF00496098.
4
Adenosine actions on CA1 pyramidal neurones in rat hippocampal slices.腺苷对大鼠海马切片中CA1锥体神经元的作用。
J Physiol. 1985 Sep;366:119-27. doi: 10.1113/jphysiol.1985.sp015788.
5
Naltrexone potentiates 4-aminopyridine seizures in the rat.纳曲酮可增强大鼠的4-氨基吡啶诱发的癫痫发作。
J Neural Transm Gen Sect. 1990;79(1-2):59-67. doi: 10.1007/BF01251001.
本文引用的文献
1
EFFECTS OF CAFFEINE ON MAMMALIAN ATRIAL MUSCLE, AND ITS INTERACTION WITH ADENOSINE AND CALCIUM.咖啡因对哺乳动物心房肌的作用及其与腺苷和钙的相互作用。
J Pharmacol Exp Ther. 1965 May;148:202-14.
2
The action of adenosine on noradrenergic neuronal inhibition induced by stimulation of locus coeruleus.腺苷对蓝斑核刺激诱导的去甲肾上腺素能神经元抑制的作用。
Brain Res. 1980 Feb 10;183(2):367-76. doi: 10.1016/0006-8993(80)90471-0.
3
Depression of corticospinal cells by various purines and pyrimidines.各种嘌呤和嘧啶对皮质脊髓细胞的抑制作用。
Can J Physiol Pharmacol. 1974 Dec;52(6):1226-9. doi: 10.1139/y74-162.
4
Purinergic nerves.嘌呤能神经
Pharmacol Rev. 1972 Sep;24(3):509-81.
5
A comparison of the effects of adenosine triphosphate with noradrenaline and with the inhibitory potential of the guinea-pig taenia coli.三磷酸腺苷与去甲肾上腺素的作用及豚鼠结肠带抑制电位的比较。
J Physiol. 1973 May;231(1):167-77. doi: 10.1113/jphysiol.1973.sp010226.
6
The effect of adenosine on the release of the transmitter from the phrenic nerve of the rat.腺苷对大鼠膈神经递质释放的影响。
J Physiol. 1972 Aug;224(3):629-45. doi: 10.1113/jphysiol.1972.sp009916.
7
Synaptic transmission in squid giant synapse after potassium conductance blockage with external 3- and 4-aminopyridine.用外部3-氨基吡啶和4-氨基吡啶阻断钾电导后乌贼巨大突触中的突触传递。
Biophys J. 1976 Jan;16(1):83-6. doi: 10.1016/S0006-3495(76)85664-0.
8
Inhibition of the calcium-induced increase in the potassium permeability of human red blood cells by quinine.奎宁对钙诱导的人红细胞钾通透性增加的抑制作用。
J Physiol. 1975 Aug;250(1):32P-33P.
9
The inhibitory effect of adenosine and related nucleotides on the release of acetylcholine.腺苷及相关核苷酸对乙酰胆碱释放的抑制作用。
Neuroscience. 1976;1(5):391-8. doi: 10.1016/0306-4522(76)90132-9.
10
A potassium contribution to the response of the barnacle photoreceptor.钾对藤壶光感受器反应的作用。
J Physiol. 1977 Aug;270(1):151-63. doi: 10.1113/jphysiol.1977.sp011943.
Zotero 插件