Lykke A W, Stewart B W, O'Connell P J, Le Mesurier S M
Pathology. 1979 Jan;11(1):71-80. doi: 10.3109/00313027909063541.
Rats exposed to an atmosphere contaminated with petrol vapour at a concentration of 100 parts per million for up to 12 weeks exhibit a high incidence of electron microscopic changes in the lung parenchyma characterized by interstitial fibrosis with associated alveolar collapse. Initial changes appearing after 6 weeks include degeneration of endothelium and interstitial fibroblasts followed by hypertrophy of Type 2 pneumocytes. Subsequent degeneration of surfactant organelles of the hypertrophied Type 2 pneumocytes correlates with the appearance of focal alveolar collapse and associated interstitial fibrosis. Because of the rapidity with which lesions are induced in the rat lung, this experimental technique provides an economical and reproducible model for an integrated study of the sequential morphological and biochemical events preceding pulmonary fibrosis which might well lead to a better understanding of the enigmatic human syndrome of fibrosing alveolitis.
将大鼠暴露于浓度为百万分之一百的汽油蒸汽污染的大气中长达12周，肺实质会出现高发生率的电子显微镜下变化，其特征为间质性纤维化并伴有肺泡塌陷。6周后出现的初始变化包括内皮细胞和间质成纤维细胞变性，随后Ⅱ型肺细胞肥大。肥大的Ⅱ型肺细胞表面活性物质细胞器的后续变性与局灶性肺泡塌陷及相关间质性纤维化的出现相关。由于在大鼠肺中诱导病变的速度很快，这种实验技术为综合研究肺纤维化之前的一系列形态学和生化事件提供了一种经济且可重复的模型，这很可能有助于更好地理解神秘的人类纤维化肺泡炎综合征。
