Lykke A W, Stewart B W
Experientia. 1978 Apr 15;34(4):498. doi: 10.1007/BF01935951.
Rats exposed to an atmosphere contaminated with gasoline vapour for 6--12 weeks exhibit progressive focal interstitial fibrosis of the lung, which is associated with irregular alveolar collapse. It is suggested that this experimental model of diffuse fibrosing lung disease constitutes a useful tool for the study of the dynamics of pulmonary reactivity to atmospheric pollutants and which may facilitate an understanding of the pathogenesis of fibrosing alveolitis in man.
暴露于含有汽油蒸汽的污染空气中6至12周的大鼠,会出现进行性局灶性肺间质纤维化,并伴有不规则的肺泡塌陷。有人认为,这种弥漫性纤维化肺病的实验模型是研究肺部对大气污染物反应动态的有用工具,可能有助于理解人类肺纤维化肺泡炎的发病机制。