Gothoskar S V, Talwalkar G V, Bhide S V
Br J Cancer. 1970 Sep;24(3):498-503. doi: 10.1038/bjc.1970.60.
Male and female Swiss strain mice were put on a 0.03% thioacetamide diet at the age of 2 months. Control mice were kept on a stock diet. Control and treated mice were killed at the ages of 6, 9, 13 and 17 months. Progressive morphological, histological and biochemical alterations in the liver and tumour tissue of the treated mice were studied. In the 17-month-old group, 12 out of 13 treated mice developed hepatomas.
2月龄时，将雄性和雌性瑞士品系小鼠置于含0.03%硫代乙酰胺的饮食中。对照小鼠维持常规饮食。对照小鼠和经处理的小鼠分别在6、9、13和17月龄时处死。研究了经处理小鼠肝脏和肿瘤组织中逐渐出现的形态学、组织学和生化改变。在17月龄组中，13只经处理的小鼠中有12只发生了肝癌。
