Date P A, Gothoskar S V, Bhide S V
J Natl Cancer Inst. 1976 Mar;56(3):493-7. doi: 10.1093/jnci/56.3.493.
Six-week-old male Swiss mice were given 0.03% thioacetamide (TAA) in the diet 24, 72, and 168 hours after partial hepatectomy. TAA-treated mice from all three groups were killed when they were 4, 9, and 13 months old. Intact and partially hepatectomized animals on normal diets served as controls. None of the controls evidenced neoplasms at any age. All three experimental groups developed liver tumors earlier than did intact mice treated with the TAA diet. Progressive metabolic studies on the livers or tumor tissues of treated mice showed that the levels of glucose-6-phosphatase, fructose-1,6-diphosphatase, and glycogen decreased significantly in the 4-month-old treated group when there was no significant alteration in liver histology. These parameters were lowest in the tumor tissues of treated mice.
六周龄雄性瑞士小鼠在部分肝切除术后24小时、72小时和168小时，于饮食中给予0.03%硫代乙酰胺（TAA）。来自所有三个组接受TAA处理的小鼠在4个月、9个月和13个月大时被处死。正常饮食的完整和部分肝切除的动物作为对照。所有对照组在任何年龄均未发现肿瘤。所有三个实验组均比接受TAA饮食处理的完整小鼠更早出现肝肿瘤。对处理过的小鼠的肝脏或肿瘤组织进行的渐进性代谢研究表明，在4个月大的处理组中，当肝脏组织学无明显改变时，葡萄糖-6-磷酸酶、果糖-1,6-二磷酸酶和糖原水平显著下降。这些参数在处理过的小鼠的肿瘤组织中最低。
