Bhide S V
Br J Cancer. 1970 Sep;24(3):504-9. doi: 10.1038/bjc.1970.61.
Sequential studies on levels of glycogen and lactic acid as well as activities of glucose-6-phosphatase, fructose-1, 6-diphosphatase aldolase, aspartic and ornithine transcarbamylase, arginase and xanthine oxidase were carried out in liver and tumour tissue of mice fed with 0.03% thioacetamide in normal stock diet. It was observed that significant decrease in glycogen content and activities of gluconeogenic enzymes was apparent at the age of 4 months, i.e. 2 months after thioacetamide treatment. Alterations in the other parameters studied were observed later, i.e. at the age of 9 months. Maximum changes were observed in the hepatomas, i.e. at the age of 17 months.
对正常普通饮食中添加0.03%硫代乙酰胺喂养的小鼠的肝脏和肿瘤组织，进行了糖原和乳酸水平以及葡萄糖-6-磷酸酶、果糖-1,6-二磷酸酶、醛缩酶、天冬氨酸和鸟氨酸转氨甲酰酶、精氨酸酶和黄嘌呤氧化酶活性的系列研究。观察到，在4月龄时，即硫代乙酰胺处理后2个月，糖原含量和糖异生酶活性明显下降。所研究的其他参数的变化在之后观察到，即9月龄时。在肝癌中观察到最大变化，即17月龄时。
