Goldenberg D M, Fisher E R
Br J Cancer. 1970 Sep;24(3):610-4. doi: 10.1038/bjc.1970.74.
Heterotransplantation of a human colonic neoplasm with classical morphologic characteristics of a carcinoid was sucessful in the cheek pouches of unconditioned, adult golden hamsters after a short sojourn in cell-impermeable chambers in rats. Although no mucin-secreting cells were detected in the donor carcinoid, the cheek pouch transplants exclusively exhibited mucinsecreting tumour cells of signet-ring type consistent with adenocarcinoma. This transplantable tumour, designated GW-77, has retained this appearance as well as expansive growth characteristics in xenogeneic hosts for a period of 4 years.These findings represent strong biological evidence consonant with views, based upon morphological findings, advocating a histogenetic relationship between colonic carcinoid and adenocarcinoma. It is believed that colonic adenocarcinoma has a selective advantage over carcinoid for serial propagation in an alien environment, indicating the less differentiated nature of its cellular components. Since the donor carcinoid cells failed to exhibit argentaffin reactions, these conclusions may be limited only to the nonreactive forms of carcinoid.
将具有类癌典型形态特征的人结肠肿瘤异种移植到未处理的成年金黄仓鼠颊囊中，移植前先将其置于大鼠的细胞不可渗透小室中短暂停留，结果移植成功。尽管在供体类癌中未检测到黏液分泌细胞，但颊囊移植瘤仅表现出与腺癌一致的印戒型黏液分泌肿瘤细胞。这种可移植肿瘤被命名为GW - 77，在异种宿主中4年一直保持这种外观以及扩张性生长特征。这些发现代表了强有力的生物学证据，与基于形态学发现而主张结肠类癌与腺癌之间存在组织发生学关系的观点一致。据信，结肠腺癌在异种环境中连续传代方面比类癌具有选择性优势，这表明其细胞成分的分化程度较低。由于供体类癌细胞未表现出嗜银反应，这些结论可能仅局限于无反应型类癌。
