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类风湿性疾病和干燥综合征中的血管炎性神经病。

Vasculitic neuropathy in rheumatoid disease and Sjögren syndrome.

作者信息

Peyronnard J M, Charron L, Beaudet F, Couture F

出版信息

Neurology. 1982 Aug;32(8):839-45. doi: 10.1212/wnl.32.8.839.

DOI:10.1212/wnl.32.8.839
PMID:6285227
Abstract

Two patients with rheumatoid arthritis and one with Sjögren syndrome had a severe sensorimotor neuropathy preceding or up to 5 years after the onset of the disease. Electrophysiologic and sural nerve biopsy studies revealed an axonal neuropathy. Myelinated fibers were affected to a greater extent than unmyelinated axons. Peripheral nerve damage was related to occlusion of the vasa nervorum, since vasculitic involvement of epineurial vessels was observed in all patients. Despite the severity of the neuropathy, it may recover, because, compared with axons, Schwann cells are perhaps less vulnerable to ischemia.

摘要

两名类风湿关节炎患者和一名干燥综合征患者在疾病发作前或发病后长达5年出现严重的感觉运动神经病变。电生理和腓肠神经活检研究显示为轴索性神经病变。有髓纤维比无髓轴突受影响的程度更大。周围神经损伤与神经滋养血管闭塞有关,因为在所有患者中均观察到神经外膜血管的血管炎累及。尽管神经病变严重,但仍可能恢复,因为与轴突相比,雪旺细胞可能对缺血的耐受性更强。

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引用本文的文献

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A Neurological Complication in Rheumatoid Arthritis - A Scenario of Catastrophic Proportions.类风湿关节炎中的一种神经系统并发症——一种具有灾难性后果的情况。
Ann Indian Acad Neurol. 2023 Jul-Aug;26(4):560-563. doi: 10.4103/aian.aian_94_23. Epub 2023 Jun 12.
2
[Sensory neuronopathy of Sjögren's syndrome. A diagnostic challenge].[干燥综合征的感觉神经元病。一项诊断挑战]
Nervenarzt. 2012 Feb;83(2):226-35. doi: 10.1007/s00115-011-3375-7.
3
Spinal cord magnetic resonance imaging demonstrates sensory neuronal involvement and clinical severity in neuronopathy associated with Sjögren's syndrome.
脊髓磁共振成像显示了干燥综合征相关神经病变中的感觉神经元受累情况及临床严重程度。
J Neurol Neurosurg Psychiatry. 2001 Oct;71(4):488-92. doi: 10.1136/jnnp.71.4.488.
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Involvement of the peripheral nervous system in primary Sjögren's syndrome.原发性干燥综合征中周围神经系统受累情况。
Ann Rheum Dis. 2001 Sep;60(9):876-81.
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Parasympathetic failure does not contribute to ocular dryness in primary Sjögren's syndrome.副交感神经功能衰竭与原发性干燥综合征的眼干无关。
Ann Rheum Dis. 1999 Dec;58(12):746-50. doi: 10.1136/ard.58.12.746.
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Peripheral neuropathy associated with primary Sjögren's syndrome.与原发性干燥综合征相关的周围神经病变
J Neurol Neurosurg Psychiatry. 1994 Aug;57(8):983-6. doi: 10.1136/jnnp.57.8.983.
7
Vasculitic neuropathy in panarteritis nodosa: clinical and ultrastructural findings.
Ital J Neurol Sci. 1986 Apr;7(2):265-9. doi: 10.1007/BF02230892.
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Axonal polyneuropathy without vasculitis, follicular lymphoma and primitive sicca syndrome. A rare association.无血管炎的轴索性多发性神经病、滤泡性淋巴瘤与原发性干燥综合征。一种罕见的关联。
Clin Rheumatol. 1990 Mar;9(1):84-7. doi: 10.1007/BF02030248.