Fiala M, Guze L B
Calif Med. 1970 May;112(5):1-6.
Rhinoviruses, prominent agents of the common cold syndrome in man, are small ribonucleic acid (rna) viruses resembling enteroviruses in their physicochemical properties except for high density and lability to acid pH. Rhinoviruses are propagated in human and monkey cells. Highest titers of virus are obtained in HeLa cell cultures. Rhinoviruses produce characteristic cytopathic effect in diploid fibroblasts. A plaque assay in HeLa cells is useful for their titration. The rhinovirus group includes many serotypes. Although rhinoviruses cause predominantly upper respiratory tract symptoms, they may on occasion infect the lower respiratory tract. Volunteers with specific antibody, when challenged with homotypic rhinovirus, are protected against the common cold.
鼻病毒是人类普通感冒综合征的主要病原体，是一种小核糖核酸（RNA）病毒，其理化性质与肠道病毒相似，只是密度高且对酸性pH不稳定。鼻病毒在人和猴细胞中繁殖。在HeLa细胞培养物中可获得最高病毒滴度。鼻病毒在二倍体成纤维细胞中产生特征性细胞病变效应。在HeLa细胞中进行蚀斑测定对其滴定很有用。鼻病毒组包括许多血清型。虽然鼻病毒主要引起上呼吸道症状，但它们偶尔也可能感染下呼吸道。具有特异性抗体的志愿者在受到同型鼻病毒攻击时可预防普通感冒。
