一些新型哌嗪喹唑啉酮作为心血管药物的合成。
Synthesis of some newer piperazinoquinazolones as cardiovascular agents.
作者信息
Dubey M, Verma V K, Shanker K, Sinha J N, Bhargava K P, Kishor K
出版信息
Pharmazie. 1979 Jan;34(1):18-20. doi: 10.1002/chin.197919284.
PMID:432250
Abstract
Twenty nine new substituted 2-methyl-3-(gamma-piperazino-propiophenyl)-4-quinazolone hydrochlorides were synthesised by the Mannich reaction of substituted quinazolones with substituted piperazines and evaluated for their cardiovascular activity. Several compounds of the series exhibited marked and sustained hypotensive activity.
摘要
通过取代喹唑啉与取代哌嗪的曼尼希反应合成了29种新的取代2-甲基-3-(γ-哌嗪基-丙酰基苯基)-4-喹唑啉盐酸盐，并对其心血管活性进行了评估。该系列中的几种化合物表现出显著且持续的降压活性。
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