感染猿猴病毒40和（或）用小牛血清处理的猴细胞中线粒体DNA合成的诱导。
Induction of mitochondrial DNA synthesis in monkey cells infected by simian virus 40 and (or) treated with calf serum.
作者信息
Levine A J
出版信息
Proc Natl Acad Sci U S A. 1971 Apr;68(4):717-20. doi: 10.1073/pnas.68.4.717.
Abstract
Infection of confluent monolayer cultures of African green monkey kidney cells with simian virus 40 results in an enhanced synthesis of nuclear and mitochondrial DNA. This is demonstrated both by an increased rate of incorporation of [(3)H]thymidine into mitochondrial DNA and by detection of increased amounts of mitochondrial DNA in infected cells. With monkey BSC-1 cells, where SV40 infection does not result in a stimulation of nuclear DNA synthesis, no stimulation of mitochondrial DNA synthesis is observed. SV40 infection of mouse 3T3 cells also stimulates nuclear and mitochondrial DNA synthesis.
摘要
用猿猴病毒40感染非洲绿猴肾细胞的汇合单层培养物会导致核DNA和线粒体DNA的合成增强。这通过将[³H]胸腺嘧啶掺入线粒体DNA的速率增加以及检测感染细胞中线粒体DNA量的增加得以证明。对于猴BSC - 1细胞，猿猴病毒40感染不会刺激核DNA合成，也未观察到对线粒体DNA合成的刺激。用猿猴病毒40感染小鼠3T3细胞也会刺激核DNA和线粒体DNA的合成。
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