肿瘤免疫：由特异性刺激淋巴细胞的可溶性产物在体内引发的肿瘤抑制。
Tumor immunity: tumor suppression in vivo initiated by soluble products of specifically stimulated lymphocytes.
作者信息
Bernstein I D, Thor D E, Zbar B, Rapp H J
出版信息
Science. 1971 May 14;172(3984):729-31. doi: 10.1126/science.172.3984.729.
PMID:4324665
Abstract
Supernatant fluids of specifically stimulated lymphocyte cultures were purified. Fractions containing migration inhibition factor when injected intra-dermally into strain-2 guinea pigs produced a reaction similar in appearance to delayed cutaneous hypersensitivity. There was an accumulation of mononuclear cells at the injection sites and the growth of syngeneic tumor grafts at the sites was suppressed.
摘要
对特异性刺激的淋巴细胞培养物的上清液进行了纯化。将含有迁移抑制因子的级分皮内注射到2型豚鼠体内时，产生了一种外观上类似于迟发型皮肤超敏反应的反应。注射部位有单核细胞聚集，且该部位同基因肿瘤移植物的生长受到抑制。
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