移植免疫中的细胞免疫吸附剂。对同种异体肿瘤致敏的小鼠淋巴细胞的特异性体外清除与恢复。
Cellular immunoabsorbents in transplantation immunity. Specific in vitro deletion and recovery of mouse lymphoid cells sensitized against allogeneic tumors.
作者信息
Berke G, Levey R H
出版信息
J Exp Med. 1972 Apr 1;135(4):972-84. doi: 10.1084/jem.135.4.972.
Abstract
Mouse lymphoid cells, sensitized against tumor allografts, can be deprived of the immunoreactive cells by in vitro absorption with specific fibroblast monolayers. Populations of lymphocytes so depleted are less effective in retarding tumor growth in vivo and in lysing tumor cells in vitro. Moreover, the adsorbed immunoreactive cells can be recovered specifically and are subsequently efficient in inhibiting tumor growth in vivo and in killing tumor cells in vitro. Further evidence is presented for the suggestion that the destruction of target cells in vitro by sensitized lymphoid cells is truly representative of the mode of destruction of grafted cells in vivo.
摘要
对肿瘤同种异体移植物致敏的小鼠淋巴细胞，可通过用特定的成纤维细胞单层进行体外吸附来去除免疫反应性细胞。如此耗尽淋巴细胞的群体在体内延缓肿瘤生长和体外裂解肿瘤细胞方面效果较差。此外，吸附的免疫反应性细胞可以被特异性回收，随后在体内抑制肿瘤生长和体外杀死肿瘤细胞方面很有效。进一步的证据表明，致敏淋巴细胞在体外对靶细胞的破坏确实代表了体内移植细胞的破坏方式。
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Studies on the immunological response to foreign tumor transplants in the mouse. I. The role of lymph node cells in conferring immunity by adoptive transfer.小鼠对外来肿瘤移植免疫反应的研究。I. 淋巴结细胞在过继性转移赋予免疫中的作用。
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Lymphocytes as mediators of cellular immunity: destruction of homologous target cells in culture.淋巴细胞作为细胞免疫的介质：培养中同源靶细胞的破坏。
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