血管紧张素对大鼠肾皮质切片阳离子转运的影响。
The effect of angiotensin on cation transport by rat kidney cortex slices.
作者信息
Munday K A, Parsons B J, Poat J A
出版信息
J Physiol. 1971 May;215(1):269-82. doi: 10.1113/jphysiol.1971.sp009468.
Abstract
- A study has been made of the effect of angiotensin (10(-12) g/ml.) on active and passive transport of sodium, potassium and water between rat kidney cortex slices and the incubation medium.2. Angiotensin has no effect on the passive uptake of sodium and loss of potassium by slices incubated under conditions which inhibit active transport.3. Active sodium extrusion by slices incubated under aerobic conditions is stimulated, whereas active potassium uptake is inhibited by angiotensin.4. Sodium pump activity is stimulated by angiotensin in the presence of ouabain or in the absence of potassium in the incubation medium, conditions which block the sodium for potassium exchange pump.5. There is a 2 min latent period following the application of angiotensin before a response is observed.6. These findings are discussed in relation to the mechanism of action of angiotensin on kidney sodium and fluid transport processes.
摘要
已经对血管紧张素（10⁻¹²克/毫升）对大鼠肾皮质切片与孵育培养基之间钠、钾和水的主动及被动转运的影响进行了研究。
在抑制主动转运的条件下孵育的切片，血管紧张素对其钠的被动摄取和钾的丢失没有影响。
在有氧条件下孵育的切片，其主动钠排出受到血管紧张素的刺激，而主动钾摄取则受到抑制。
在存在哇巴因或孵育培养基中无钾的情况下，血管紧张素刺激钠泵活性，这些条件会阻断钠钾交换泵。
施加血管紧张素后有2分钟的潜伏期，之后才观察到反应。
就血管紧张素对肾脏钠和液体转运过程的作用机制对这些发现进行了讨论。
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