Burrows R, Mann J A, Greig A, Chapman W G, Goodridge D
J Hyg (Lond). 1971 Jun;69(2):307-21. doi: 10.1017/s0022172400021537.
In animals exposed to foot-and-mouth disease virus by indirect contact, virus was recovered from the blood, milk, pharynx, vagina and rectum for variable periods of time before clinical disease was apparent. Virus instilled into the mammary gland multiplied rapidly and virus concentrations greater than 10(7) p.f.u./ml. were recorded within 8-32 hr., depending on the virus strain and dose inoculated. Virus multiplication was accompanied by clinical signs of mastitis but the classical signs of foot-and-mouth disease did not appear for 52-117 hr. Dissemination of virus from the mammary gland occurred within 4-24 hr. and in some animals samples taken from the pharynx, mouth, nose and vagina contained virus for periods up to 97 hr. before the appearance of vesicular lesions. Virus production in the udder declined with the appearance of virus neutralizing activity in the blood and the milk but persisted in some animals for periods of 3-7 weeks. The ability of foot-and-mouth disease virus to persist in mammary tissue was confirmed by the demonstration of virus multiplication in the udders of immune animals.
在通过间接接触感染口蹄疫病毒的动物中，在临床疾病显现之前的不同时间段内，可从血液、乳汁、咽部、阴道和直肠中分离到病毒。将病毒注入乳腺后迅速增殖，8至32小时内病毒浓度超过10(7) 蚀斑形成单位/毫升，这取决于病毒株和接种剂量。病毒增殖伴随着乳腺炎的临床症状，但口蹄疫的典型症状在52至117小时后才出现。病毒在4至24小时内从乳腺扩散，在一些动物中，在水疱性病变出现前长达97小时，从咽部、口腔、鼻子和阴道采集的样本中都含有病毒。随着血液和乳汁中病毒中和活性的出现，乳腺中的病毒产生量下降，但在一些动物中持续3至7周。通过在免疫动物的乳腺中证明病毒增殖，证实了口蹄疫病毒在乳腺组织中持续存在的能力。
