长期服用芬氟拉明：一些对大脑的影响。
Chronic fenfluramine administration: some cerebral effects.
作者信息
Lewis S A, Oswald I, Dunleavy D L
出版信息
Br Med J. 1971 Jul 10;3(5766):67-70. doi: 10.1136/bmj.3.5766.67.
Abstract
Human cerebral function was monitored electrophysiologically during sleep over a period of months before, during, and after the intake of fenfluramine, 40-120 mg/day. Effects included dose-related reduction of paradoxical sleep, increase of intra-sleep restlessness, and changes in E.E.G. slow-wave sleep. It is hypothesized that weight loss may be associated with increase of the last. Grinding of teeth (bruxism) also was noted.Long-term studies make it possible to demonstrate changing central effects with time, including tolerance phenomena. Withdrawal abnormalities are related to the time taken for the drug to be eliminated-in the present case reaching a maximum four days after withdrawal.
摘要
在摄入氟苯丙胺（每天40 - 120毫克）之前、期间和之后的几个月里，通过电生理学方法对人类大脑功能进行了睡眠期间的监测。其影响包括与剂量相关的异相睡眠减少、睡眠中不安增加以及脑电图慢波睡眠的变化。据推测，体重减轻可能与后者的增加有关。还观察到了磨牙（磨牙症）现象。长期研究使得能够证明随着时间推移中枢效应的变化，包括耐受性现象。戒断异常与药物消除所需时间有关——在本案例中，戒断后四天达到最大值。
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