虽非滥用但具依赖性的药物：芬氟拉明和丙咪嗪。
Drugs of dependence though not of abuse: fenfluramine and imipramine.
作者信息
Oswald I, Lewis S A, Dunleavy D L, Brezinova V, Briggs M
出版信息
Br Med J. 1971 Jul 10;3(5766):70-3. doi: 10.1136/bmj.3.5766.70.
Measures of subjective feeling used by five patients indicated that depression of mood occurred about four days after fenfluramine withdrawal. An experiment in which another 11 patients took fenfluramine 80 mg for 28 days confirmed the depression, maximal on the fourth withdrawal day. It also indicated that in the first week of administration there was some mood elevation, but with feelings of impaired ability to concentrate. The drug reduced appetite and weight. A comparison is drawn with imipramine, which was found to induce initial and withdrawal changes of subjective experience (of dreaming) in six volunteers. It is suggested that certain mood-influencing drugs may not be drugs of abuse because of some unpleasant initial effects, though they can be drugs of dependence.
五名患者使用的主观感受测量方法表明，停用芬氟拉明后约四天出现情绪低落。另一项实验中，11名患者服用80毫克芬氟拉明，持续28天，证实了情绪低落，在停药第四天最为严重。该实验还表明，在用药的第一周，情绪有所提升，但伴有注意力难以集中的感觉。该药能降低食欲和体重。文中将其与丙咪嗪进行了比较，丙咪嗪在六名志愿者身上引发了主观体验（梦境方面）的初始变化和停药变化。研究表明，某些影响情绪的药物可能因其一些令人不适的初始效应而不属于滥用药物，尽管它们可能会让人产生依赖性。
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