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I型高脂蛋白血症中的脾脏。组织化学、生物化学、显微荧光测定法及电子显微镜观察

The spleen in type I hyperlipoproteinemia. Histochemical, biochemical, microfluorometric and electron microscopic observations.

作者信息

Ferrans V J, Buja L M, Roberts W C, Fredrickson D S

出版信息

Am J Pathol. 1971 Jul;64(1):67-96.

PMID:4326635
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2047553/
Abstract

Histochemical, biochemical, microfluorometric and electron microscopic studies were made of the spleen of a patient with type I hyperlipoproteinemia. Foam cells were observed that contained a material identified as ceroid on the basis of its autofluorescence, acid-fastness, sudanophilia, PAS-positivity and insolubility in organic solvents. Electron microscopy showed that the ceroid was organized in the form of granules with concentric lamellae of irregular periodicity. The process of formation of these granules is described in detail. The ceroid was considered to represent nondigestible end products of the metabolism of chylomicrons taken up by macrophages in splenic sinusoids.

摘要

对一名患有I型高脂蛋白血症患者的脾脏进行了组织化学、生物化学、显微荧光测定和电子显微镜研究。观察到泡沫细胞含有一种物质，根据其自身荧光、抗酸性、嗜苏丹性、PAS阳性以及在有机溶剂中的不溶性，该物质被鉴定为类蜡质。电子显微镜显示类蜡质呈颗粒状，具有不规则周期性的同心薄片。详细描述了这些颗粒的形成过程。类蜡质被认为代表了脾血窦中巨噬细胞摄取的乳糜微粒代谢的不可消化终产物。

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本文引用的文献

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Am J Pathol. 1944 Jan;20(1):149-53.
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Lipoid-Containing Cells in the Spleen in Diabetes with Lipemia.糖尿病伴脂血症患者脾脏中含脂质的细胞
Am J Pathol. 1926 Jan;2(1):69-80.3.
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CLINICOPATHOLOGICAL CONFERENCE.临床病理讨论会
I型高脂蛋白血症中乳糜微粒与泡沫细胞的形成。一项形态学研究。
Am J Pathol. 1973 Feb;70(2):253-72.
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Deposition of lipopigment--a new feature of human splenic sinus endothelium (SSE). Ultrastructural and histochemical study.脂色素沉积——人类脾窦内皮细胞（SSE）的一个新特征。超微结构和组织化学研究。
Virchows Arch A Pathol Anat Histopathol. 1990;416(5):423-8. doi: 10.1007/BF01605148.
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So-called neuronal ceroid-lipofuscinosis. Histochemical study with evidence of extractibility of the stored material.所谓的神经元蜡样脂褐质沉积症。组织化学研究及储存物质可提取性的证据。
Acta Neuropathol. 1977 May 16;38(2):117-22. doi: 10.1007/BF00688557.
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The pathology of Tangier disease. A light and electron microscopic study.Tangier病的病理学。光镜和电镜研究。
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Cellular pathology of homozygous familial hypercholesterolemia.纯合子家族性高胆固醇血症的细胞病理学
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