Nakama T, Furusawa T, Itoh H, Hisadome T
Gastroenterol Jpn. 1979 Dec;14(6):565-72. doi: 10.1007/BF02773715.
Not only cholesterol but also bilirubin were considered to be solubilized by bile salt micelles. The correlation of cholesterol and bilirubin solubilization in aqueous conjugated and unconjugated bile salts solution and the effect of calcium on their solubilization were studied in this report. Cholesterol solubilization was usually reduced to some extent with increasing amount of added bilirubin. Bilirubin solubilization was always reduced by the co-existence of solubilized cholesterol. It was found that the addition of calcium increased cholesterol solubilization in conjugated bile salts system. On the other hand, calcium reduced bilirubin solubilization due to the formation of insoluble calcium bilirubinate especially in a high pH range of unconjugated bile salts system. Cholesterol solubilization in conjugated bile salts system was relatively lower than unconjugated bile salts system with or without added calcium, however co-existing bilirubin minimized these differences. The pH-dependency of cholesterol and bilirubin solubilization was small in conjugated bile salts system. On the contrary, it was remarkably bigger in unconjugated bile salts-calcium system.
不仅胆固醇，胆红素也被认为可被胆盐微团溶解。本报告研究了在共轭和非共轭胆盐水溶液中胆固醇和胆红素溶解的相关性以及钙对它们溶解的影响。随着胆红素添加量的增加，胆固醇的溶解通常会在一定程度上降低。已溶解胆固醇的共存总是会降低胆红素的溶解。研究发现，添加钙会增加共轭胆盐体系中胆固醇的溶解。另一方面，由于不溶性胆红素钙的形成，钙会降低胆红素的溶解，尤其是在非共轭胆盐体系的高pH范围内。无论有无添加钙，共轭胆盐体系中胆固醇的溶解相对低于非共轭胆盐体系，然而共存的胆红素会使这些差异最小化。在共轭胆盐体系中，胆固醇和胆红素溶解的pH依赖性较小。相反，在非共轭胆盐 - 钙体系中，这种依赖性则明显更大。
