Wosiewitz U, Sabinski F
Hepatogastroenterology. 1983 Oct;30(5):184-7.
Calcium bilirubinate, an important constituent of pigment gallstones, can be solubilized in aqueous systems (including bile) to a considerable extent, depending on colloid mechanisms, strongly influenced by the actual ionic strength. Simple bile salt micelles protect colloid calcium bilirubinate against coagulation more effectively than do mixed bile salt-lecithin micelles, in particular when the latter are cholesterol saturated. The dissolved pigment does not enter the bile salt micelle. Pigment stone formation is believed to be due not merely to calcium bilirubinate overproduction, but also to pathological conditions leading to a coagulation of the colloid pigment in bile.
胆红素钙是色素性胆结石的重要成分，根据胶体机制，它在水性体系（包括胆汁）中能在很大程度上溶解，而这受到实际离子强度的强烈影响。简单的胆盐微团比混合的胆盐 - 卵磷脂微团更有效地保护胶体胆红素钙不发生凝聚，尤其是当后者胆固醇饱和时。溶解的色素不会进入胆盐微团。色素结石的形成被认为不仅是由于胆红素钙产生过多，还归因于导致胆汁中胶体色素凝聚的病理状况。
