Rock G A, Tittley P
Transfusion. 1979 Jan-Feb;19(1):86-9. doi: 10.1046/j.1537-2995.1979.19179160274.x.
The effect of temperature on Factor VIII levels in blood and cryoprecipitate was assessed. Freshw collected units of blood required several hours to reach 4 C, but this delay seemed of little importance since equal amounts of cryoprecipitated Factor VIII were recovered from blood stored either at 22 C or at 4 C. Freezing at -80, -60, or -40 C produced identical yields of Factor VIII, whereas freezing at -20 C resulted in significantly lower recoveries. This might be expected if one considers the physiochemical changes that occur during the freezing process.
评估了温度对血液和冷沉淀物中凝血因子VIII水平的影响。新鲜采集的血液单位需要几个小时才能达到4°C，但这种延迟似乎不太重要，因为从22°C或4°C储存的血液中回收的冷沉淀凝血因子VIII量相等。在-80°C、-60°C或-40°C冷冻产生的凝血因子VIII产量相同，而在-20°C冷冻导致回收率显著降低。如果考虑冷冻过程中发生的物理化学变化，这是可以预料的。
