[白喉毒素对豚鼠肝细胞核组蛋白释放及可提取性的影响]
[Effect of diphtheria toxin on the release and extractability of histones from the liver cell nuclei of guinea pigs].
作者信息
Gamelina L Sh, Ovchinnikova L P, Braun A D
出版信息
Tsitologiia. 1979 Feb;21(2):214-7.
PMID:432962
Abstract
The release and extraction of histones from the nuclei of guinea pig liver under the influence of diphteria toxin was investigated in vivo and in vitro. A considerable loss of nuclear histones, increase of easily extracted arginine-rich histones and a more complete extraction of lysine-rich ones have been shown. A possible role of histones in the development of diphteria intoxication is discussed.
摘要
研究了在体内和体外条件下，白喉毒素影响下豚鼠肝细胞核中组蛋白的释放和提取情况。结果显示，细胞核组蛋白有相当程度的损失，富含精氨酸的组蛋白更容易提取，且富含赖氨酸的组蛋白提取得更完全。文中还讨论了组蛋白在白喉中毒发展过程中可能发挥的作用。
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