[Effect of diphtheria toxin on the release and extractability of histones from the liver cell nuclei of guinea pigs].

The release and extraction of histones from the nuclei of guinea pig liver under the influence of diphteria toxin was investigated in vivo and in vitro. A considerable loss of nuclear histones, increase of easily extracted arginine-rich histones and a more complete extraction of lysine-rich ones have been shown. A possible role of histones in the development of diphteria intoxication is discussed.