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抗坏血酸缺乏豚鼠中促肾上腺皮质激素活性的抑制

Suppression of adrenocorticotrophic activity in the ascorbic acid deficient guinea-pig.

作者信息

Hodges J R, Hotston R T

出版信息

Br J Pharmacol. 1971 Aug;42(4):595-602. doi: 10.1111/j.1476-5381.1971.tb07143.x.

DOI:10.1111/j.1476-5381.1971.tb07143.x
PMID:4329984
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1665767/
Abstract
  1. Adrenocortical hyperactivity caused by a marked increase in circulating corticotrophin occurred in guinea-pigs on a diet deficient in ascorbic acid.2. Betamethasone prevented the rise in the blood ACTH concentration in scorbutic animals and also the increased steroid production per gramme adrenal tissue in vitro. It diminished the adrenal hypertrophy and partially suppressed the rise in plasma cortisol.3. Ninety minutes after the injection of ascorbic acid corticotrophin could no longer be detected in the plasma of scorbutic animals.4. Neither the survival time nor the weight loss was affected by betamethasone treatment.
摘要

  1. 饮食中缺乏抗坏血酸的豚鼠会出现循环促肾上腺皮质激素显著增加导致的肾上腺皮质功能亢进。

  2. 倍他米松可防止坏血病动物血液中促肾上腺皮质激素（ACTH）浓度升高，也可防止体外每克肾上腺组织类固醇生成增加。它减轻了肾上腺肥大，并部分抑制了血浆皮质醇的升高。

  3. 注射抗坏血酸90分钟后，坏血病动物血浆中已检测不到促肾上腺皮质激素。

  4. 倍他米松治疗对存活时间和体重减轻均无影响。

相似文献

1
Suppression of adrenocorticotrophic activity in the ascorbic acid deficient guinea-pig.抗坏血酸缺乏豚鼠中促肾上腺皮质激素活性的抑制
Br J Pharmacol. 1971 Aug;42(4):595-602. doi: 10.1111/j.1476-5381.1971.tb07143.x.
2
Effect of ascorbic acid on guinea pig adrenal adenylate cyclase activity and plasma cortisol.
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Ascorbic acid deficiency and pituitary adrenocortical activity in the guinea-pig.豚鼠体内的抗坏血酸缺乏与垂体肾上腺皮质活动
Br J Pharmacol. 1970 Dec;40(4):740-6. doi: 10.1111/j.1476-5381.1970.tb10651.x.
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Influence of vitamin C restriction on guinea pig adrenal calcium and plasma corticosteroids.
J Nutr. 1977 Oct;107(10):1846-51. doi: 10.1093/jn/107.10.1846.
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Plasma cortisol and adrenal ascorbic acid levels after ACTH treatment with a high intake of ascorbic acid in the guinea pig.
Ann Nutr Metab. 1990;34(2):85-92. doi: 10.1159/000177573.
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Metabolic availability of ascorbic acid in female guinea-pigs.雌性豚鼠中抗坏血酸的代谢可用性。
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Ascorbate depletion prevents aldosterone stimulation by sodium deficiency in the guinea pig.
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Uptake and release of adrenal ascorbic acid in the guinea pig after injection of ACTH.
J Nutr. 1987 Sep;117(9):1570-5. doi: 10.1093/jn/117.9.1570.
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Role of ascorbic acid on tyrosine hydroxylase activity in the adrenal gland of guinea pig.
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Ascorbic acid and cortisol metabolism in hypovitaminosis C guineapigs.维生素C缺乏豚鼠体内的抗坏血酸和皮质醇代谢
Int J Vitam Nutr Res. 1982;52(2):176-85.

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Vitamin C Transporters, Recycling and the Bystander Effect in the Nervous System: SVCT2 versus Gluts.维生素C转运体、循环利用与神经系统中的旁观者效应：钠依赖性维生素C转运体2（SVCT2）与葡萄糖转运蛋白（Gluts）
J Stem Cell Res Ther. 2014 May 19;4(5):209. doi: 10.4172/2157-7633.1000209.
2
Hypothalamo-pituitary adrenocortical function in the rat after treatment with betamethasone.大鼠经倍他米松治疗后下丘脑-垂体-肾上腺皮质功能
Br J Pharmacol. 1976 Feb;56(2):235-9. doi: 10.1111/j.1476-5381.1976.tb07447.x.

本文引用的文献

1
Potentiating effect of ascorbic acid on cortisone-induced gluconeogenesis.
Proc Soc Exp Biol Med. 1952 Apr;79(4):648-50. doi: 10.3181/00379727-79-19474.
2
Some effects of cortisone on vitamin C-deficient guinea pigs.
Endocrinology. 1952 Feb;50(2):259-63. doi: 10.1210/endo-50-2-259.
3
Relation of adrenal cortical function to scurvy in guinea-pigs; preliminary experiments.豚鼠肾上腺皮质功能与坏血病的关系；初步实验
Br Med J. 1951 Oct 20;2(4737):927-30. doi: 10.1136/bmj.2.4737.927.
4
Effect of cortisone and adrenocorticotrophic hormone (ACTH) on experimental scurvy in the guinea pig.
Proc Soc Exp Biol Med. 1950 Nov;75(2):470-5. doi: 10.3181/00379727-75-18235.
5
The relation of ascorbic acid to adrenocortical function during cold stress.
Endocrinology. 1955 Apr;56(4):413-9. doi: 10.1210/endo-56-4-413.
6
Corticotrophin release in the cortisol-treated rat.皮质醇处理大鼠中的促肾上腺皮质激素释放
J Physiol. 1962 Oct;163(3):391-8. doi: 10.1113/jphysiol.1962.sp006984.
7
Pituitary and blood corticotrophin changes in adrenalectomized rats maintained on physiological doses of corticosteroids.
Acta Endocrinol (Copenh). 1962 Jan;39:79-86. doi: 10.1530/acta.0.0390079.
8
The effect of corticotropin on the formation of corticosteroids in vitro.
Can J Biochem Physiol. 1961 Jan;39:23-9. doi: 10.1139/o61-004.
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Circulating corticotrophin in normal and adrenalectomized rats after stress.
Acta Endocrinol (Copenh). 1959 Feb;30(2):188-96. doi: 10.1530/acta.0.0300188.
10
The estimation of small amounts of corticosterone in rat plasma.大鼠血浆中少量皮质酮的测定。
J Biol Chem. 1958 Apr;231(2):695-701.