抗坏血酸缺乏豚鼠中促肾上腺皮质激素活性的抑制
Suppression of adrenocorticotrophic activity in the ascorbic acid deficient guinea-pig.
作者信息
Hodges J R, Hotston R T
出版信息
Br J Pharmacol. 1971 Aug;42(4):595-602. doi: 10.1111/j.1476-5381.1971.tb07143.x.
Abstract
- Adrenocortical hyperactivity caused by a marked increase in circulating corticotrophin occurred in guinea-pigs on a diet deficient in ascorbic acid.2. Betamethasone prevented the rise in the blood ACTH concentration in scorbutic animals and also the increased steroid production per gramme adrenal tissue in vitro. It diminished the adrenal hypertrophy and partially suppressed the rise in plasma cortisol.3. Ninety minutes after the injection of ascorbic acid corticotrophin could no longer be detected in the plasma of scorbutic animals.4. Neither the survival time nor the weight loss was affected by betamethasone treatment.
摘要
饮食中缺乏抗坏血酸的豚鼠会出现循环促肾上腺皮质激素显著增加导致的肾上腺皮质功能亢进。
倍他米松可防止坏血病动物血液中促肾上腺皮质激素（ACTH）浓度升高，也可防止体外每克肾上腺组织类固醇生成增加。它减轻了肾上腺肥大，并部分抑制了血浆皮质醇的升高。
注射抗坏血酸90分钟后，坏血病动物血浆中已检测不到促肾上腺皮质激素。
倍他米松治疗对存活时间和体重减轻均无影响。
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本文引用的文献
1
Potentiating effect of ascorbic acid on cortisone-induced gluconeogenesis.
Proc Soc Exp Biol Med. 1952 Apr;79(4):648-50. doi: 10.3181/00379727-79-19474.
2
Some effects of cortisone on vitamin C-deficient guinea pigs.
Endocrinology. 1952 Feb;50(2):259-63. doi: 10.1210/endo-50-2-259.
3
Relation of adrenal cortical function to scurvy in guinea-pigs; preliminary experiments.豚鼠肾上腺皮质功能与坏血病的关系；初步实验
Br Med J. 1951 Oct 20;2(4737):927-30. doi: 10.1136/bmj.2.4737.927.
4
Effect of cortisone and adrenocorticotrophic hormone (ACTH) on experimental scurvy in the guinea pig.
Proc Soc Exp Biol Med. 1950 Nov;75(2):470-5. doi: 10.3181/00379727-75-18235.
5
The relation of ascorbic acid to adrenocortical function during cold stress.
Endocrinology. 1955 Apr;56(4):413-9. doi: 10.1210/endo-56-4-413.
6
Corticotrophin release in the cortisol-treated rat.皮质醇处理大鼠中的促肾上腺皮质激素释放
J Physiol. 1962 Oct;163(3):391-8. doi: 10.1113/jphysiol.1962.sp006984.
7
Pituitary and blood corticotrophin changes in adrenalectomized rats maintained on physiological doses of corticosteroids.
Acta Endocrinol (Copenh). 1962 Jan;39:79-86. doi: 10.1530/acta.0.0390079.
8
The effect of corticotropin on the formation of corticosteroids in vitro.
Can J Biochem Physiol. 1961 Jan;39:23-9. doi: 10.1139/o61-004.
9
Circulating corticotrophin in normal and adrenalectomized rats after stress.
Acta Endocrinol (Copenh). 1959 Feb;30(2):188-96. doi: 10.1530/acta.0.0300188.
10
The estimation of small amounts of corticosterone in rat plasma.大鼠血浆中少量皮质酮的测定。
J Biol Chem. 1958 Apr;231(2):695-701.
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