关于致癌物N-羟基-N-2-乙酰氨基芴的代谢活化。3. 用辣根过氧化物酶氧化生成2-亚硝基芴和N-乙酰氧基-N-2-乙酰氨基芴。 - Suppr

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On the metabolic activation of the carcinogen N-hydroxy-N-2-acetylaminofluorene. 3. Oxidation with horseradish peroxidase to yield 2-nitrosofluorene and N-acetoxy-N-2-acetylaminofluorene.

作者信息

Bartsch H, Hecker E

出版信息

Biochim Biophys Acta. 1971 Jun 22;237(3):567-78. doi: 10.1016/0304-4165(71)90277-7.

DOI:10.1016/0304-4165(71)90277-7

PMID:4330271

Abstract

摘要

相似文献

On the metabolic activation of the carcinogen N-hydroxy-N-2-acetylaminofluorene. 3. Oxidation with horseradish peroxidase to yield 2-nitrosofluorene and N-acetoxy-N-2-acetylaminofluorene.关于致癌物N-羟基-N-2-乙酰氨基芴的代谢活化。3. 用辣根过氧化物酶氧化生成2-亚硝基芴和N-乙酰氧基-N-2-乙酰氨基芴。

Biochim Biophys Acta. 1971 Jun 22;237(3):567-78. doi: 10.1016/0304-4165(71)90277-7.

On the metabolic activation of N-hydroxy-N-2-acetylamino-fluorene. II. Simultaneous formation of 2-nitrosofluorene and N-acetoxy-N-2-acetylaminofluorene from N-hydroxy-N-2-acetylaminofluorene via a free radical intermediate.论N-羟基-N-2-乙酰氨基芴的代谢活化。II. 经由自由基中间体从N-羟基-N-2-乙酰氨基芴同时生成2-亚硝基芴和N-乙酰氧基-N-2-乙酰氨基芴

Biochim Biophys Acta. 1971 Jun 22;237(3):556-66. doi: 10.1016/0304-4165(71)90276-5.

Horseradish peroxidase/hydrogen peroxide-catalyzed oxidation of the carcinogen N-hydroxy-N-acetyl-2-aminofluorene as effected by cyanide and ascorbate.辣根过氧化物酶/过氧化氢催化致癌物N-羟基-N-乙酰-2-氨基芴的氧化反应：氰化物和抗坏血酸的影响

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Acetylation of the carcinogen N-hydroxy-2-acetylaminofluorene by acetyl Coenzyme A to form a reactive ester.致癌物N-羟基-2-乙酰氨基芴被乙酰辅酶A乙酰化，形成一种活性酯。

Mol Pharmacol. 1971 Jul;7(4):381-8.

Free radicals and carcinogenesis. Some properties of the nitroxyl free radicals produced by covalent binding of 2-nitrosofluorene to unsaturated lipids of membranes.

Arch Biochem Biophys. 1978 Jan 30;185(2):450-7. doi: 10.1016/0003-9861(78)90188-1.

N-acetoxy-N-acetylaminoarenes and nitrosoarenes. One-electron non-enzymatic and enzymatic oxidation products of various carcinogenic aromatic acethydroxamic acids.N-乙酰氧基-N-乙酰氨基芳烃和亚硝基芳烃。各种致癌芳香族乙酰氧肟酸的单电子非酶促和酶促氧化产物。

Biochim Biophys Acta. 1972 Jun 26;273(1):40-51. doi: 10.1016/0304-4165(72)90189-4.

Free radical activation of N-hydroxy-2-acetylaminofluorene by methemoglobin and hydrogen peroxide.

Cancer Biochem Biophys. 1979;4(2):87-93.

Lipid hydroperoxide activation of N-hydroxy-N-acetylaminofluorene via a free radical route.

Cancer Res. 1976 Aug;36(8):2761-7.

Cytochrome c/H2O2-mediated one electron oxidation of carcinogenic N-fluorenylacetohydroxamic acids to nitroxyl free radicals.细胞色素c/过氧化氢介导的致癌性N-芴基乙酰氧肟酸单电子氧化生成硝酰自由基。

Chem Biol Interact. 1983 Sep 15;46(3):317-34. doi: 10.1016/0009-2797(83)90016-9.

Studies on cytochrome c peroxidase. 18. Recombination of apoenzyme with protoporphyrin and protoheme monomethyl esters.

J Biol Chem. 1972 Apr 25;247(8):2278-82.

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Proc Natl Acad Sci U S A. 1981 Apr;78(4):2003-7. doi: 10.1073/pnas.78.4.2003.

Comparative studies on the cumene hydroperoxide- and NADPH-supported N-oxidation of 4-chloroaniline by cytochrome P-450.细胞色素P-450对异丙苯过氧化氢和NADPH支持的4-氯苯胺N-氧化作用的比较研究。

Biochem J. 1983 Jun 15;212(3):539-47. doi: 10.1042/bj2120539.

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Pathobiologic and metabolic aspects of mammary gland tumorigenesis by N-substituted aryl compounds.N-取代芳基化合物诱发乳腺肿瘤发生的病理生物学和代谢方面

Environ Health Perspect. 1983 Mar;49:175-83. doi: 10.1289/ehp.8349175.

Ultimate electrophilic carcinogens on cellular nucleophilic reactants. A contribution to the discussion on threshold doses of environmental chemicals.作用于细胞亲核反应物的终极亲电致癌物。对环境化学品阈剂量讨论的一份贡献。

Arch Toxicol. 1974 Mar 29;32(1):27-38. doi: 10.1007/BF00334609.

Role of radical cations in aromatic hydrocarbon carcinogenesis.自由基阳离子在芳烃致癌作用中的作用。

Environ Health Perspect. 1985 Dec;64:69-84. doi: 10.1289/ehp.856469.

Activation of the carcinogen N-hydroxy-2-acetylaminofluorene by rat mammary peroxidase.

Experientia. 1978 Jan 15;34(1):107-8. doi: 10.1007/BF01921931.

Free radicals produced in a nitrosofluorene-unsaturated lipid reaction.

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