大鼠体内视黄酸的代谢研究。
Metabolic studies on retinoic acid in the rat.
作者信息
Sundaresan P R, Bhagavan H N
出版信息
Biochem J. 1971 Mar;122(1):1-4. doi: 10.1042/bj1220001.
Abstract
The nature of metabolites in the urine arising from differentially labelled retinoic acid was investigated after injection of physiological doses into retinol-deficient rats. Distribution of radioactivity after partition of urine into ether-soluble, acidic and water-soluble fractions revealed that there were at least six metabolites in urine. Of these, the major metabolite(s) was one lacking both C-14 and C-15 of retinoic acid. Enzymic or alkaline hydrolysis of acidic and water-soluble fractions did not release any retinoic acid, thus indicating that retinoyl beta-glucuronide was not present in urine in significant amounts.
摘要
在向维生素A缺乏的大鼠注射生理剂量的视黄酸后，研究了尿液中由不同标记的视黄酸产生的代谢物的性质。将尿液分成醚溶性、酸性和水溶性部分后，放射性分布表明尿液中至少有六种代谢物。其中，主要代谢物是一种既缺乏视黄酸的C-14又缺乏C-15的代谢物。酸性和水溶性部分的酶促水解或碱性水解均未释放出任何视黄酸，因此表明尿液中不存在大量的视黄酰β-葡萄糖醛酸苷。
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