前列腺素及其对人胎盘腺苷酸环化酶的影响。
Prostaglandins and their effects on human placental adenyl cyclase.
作者信息
Satoh K, Ryan K J
出版信息
J Clin Invest. 1972 Feb;51(2):456-8. doi: 10.1172/JCI106832.
Abstract
Prostaglandins increased adenyl cyclase activity in human term placental homogenates in a dose-dependent manner during 10-min incubation periods. The potency of the prostaglandins examined was demonstrated to be in the ascending order, prostaglandin F(1alpha) < A(2), F(2alpha), B(2) < A(1) < E(2) < E(1). Although no specific trophic or regulating factors for placental function have been described as yet, it is possible that prostaglandins which are synthesized in decidual tissue could play such a physiological role.
摘要
在10分钟的孵育期内，前列腺素以剂量依赖的方式增加人足月胎盘匀浆中的腺苷酸环化酶活性。所检测的前列腺素的效力呈升序排列，即前列腺素F(1α) < A(2)、F(2α)、B(2) < A(1) < E(2) < E(1)。尽管尚未描述胎盘功能的特异性营养或调节因子，但在蜕膜组织中合成的前列腺素可能发挥这样的生理作用。
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