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原发性肺肉瘤与肺癌相比对病因学的贡献(作者译)

[Contribution to aetiology by the primary pulmonary sarcoma in comparison to the pulmonary carcinoma (author's transl)].

作者信息

Gebauer C

出版信息

Z Erkr Atmungsorgane. 1979;152(1):51-60.

PMID:433329
Abstract

On 41 primary pulmonary sarcomas in the years 1957 till 1974 and on 192 pulmonary carcinomas in the year 1969 cancerogene noxes and endogene factors were analysed, compared and discussed with literature. Smoking of cigarettes, chronic bronchitis and radioactive radiation at underground mining are also significantly accumulated in our study and are recognized as cancerogenes. There is no correlation between pulmonary sarcomas and these exogene factors. The constant frequency in the last decades, the non-existing sex disposition, the ten till fifteen years lower sarcoma manifestation with a continuous increase already in the second decade of life and the protected position of the mesenchyme do not suggest a causal connexion between exogene cancerogene influence and pulmonary sarcoma formation. Rather make us suppose an endogene tumour disposition. Pulmonary sarcomas correlate as to localisation, sex relation and not provable exogene cancerogena with the adenocarcinoma of the lungs. The causal connexion between trauma and sarcoma formation in a thoracotomy cicatrice as well as the possibility of a sarcomatous degeneration are discussed.

摘要

对1957年至1974年间的41例原发性肺肉瘤以及1969年的192例肺癌的致癌因素和内源性因素进行了分析、比较,并与文献进行了讨论。在我们的研究中,吸烟、慢性支气管炎和地下采矿时的放射性辐射也有显著聚集,并被认为是致癌因素。肺肉瘤与这些外源性因素之间没有相关性。在过去几十年中发病率恒定,不存在性别倾向,肉瘤表现比腺癌晚10至15年,且在生命的第二个十年就已经持续增加,间充质的保护作用并不表明外源性致癌影响与肺肉瘤形成之间存在因果关系。相反,这使我们推测存在内源性肿瘤易感性。肺肉瘤在定位、性别关系以及无法证实的外源性致癌因素方面与肺腺癌相关。文中还讨论了开胸手术瘢痕中创伤与肉瘤形成之间的因果关系以及肉瘤变性的可能性。

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