Höpker W W, Bohrer M H, Storch B
Z Gastroenterol. 1979 Mar;17(3):162-70.
The mean incidence age for rectal carcinoma in women rose significantly in the township of Karlsruhe between 1971-1975 from 61,5 to 70,9 years, while the incidence age for colon carcinoma in men decreased significantly from 67,5 to 65,0 years. In the world incidence statistics of colon carcinoma in males, Karlsruhe ranks 16th (13,2 cases per 100 000 inhabitants), whereas the city ranks second for rectal carcinoma in males (18,5 cases/100 000). Prevalence patterns of gastric, colonic, and rectal carcinoma differ between individual districts of Karlsruhe. Time-related pathogenetic influence factors are discussed in extenso.
1971年至1975年间，卡尔斯鲁厄镇女性直肠癌的平均发病年龄显著上升，从61.5岁升至70.9岁，而男性结肠癌的发病年龄则从67.5岁显著降至65.0岁。在全球男性结肠癌发病率统计中，卡尔斯鲁厄排名第16位（每10万居民中有13.2例），而在男性直肠癌发病率方面，该市排名第二（每10万居民中有18.5例）。卡尔斯鲁厄各个区的胃癌、结肠癌和直肠癌患病率模式有所不同。文中详细讨论了与时间相关的致病影响因素。
