Arnold A J, Simpson J G, Jones H E, Ahmed A R
J Am Acad Dermatol. 1979 Dec;1(6):509-12. doi: 10.1016/s0190-9622(79)80094-8.
This study evaluates the ability of hydroxyzine and various neuroleptics to suppress histamine-induced pruritus in ten volunteer subjects with the use of a double-blind crossover protocol. The itch threshold was determined in each volunteer by intradermal injection of gradually increasing concentrations of histamine. Volunteers were then given the study drugs and placebo at the same interval of time, under near identical conditions, and the itch threshold was determined. Thiothixene, hydroxyzine hydrochloride, chlorpromazine, thioridazine, and a lactose placebo were evaluated. Compared to other drugs, hydroxyzine alone was more effective in the suppression of histamine-induced itch. Consequently, hydrozyzine may be more effective in histamine-induced pruritus. The neuroleptic drugs used in this study do not significantly suppress histamine-induced pruritus, but they may be beneficial in nonhistamine-induced pruritus or psychogenic pruritus.
本研究采用双盲交叉试验方案，评估了羟嗪和各种抗精神病药物对10名志愿者组胺诱导瘙痒的抑制能力。通过皮内注射逐渐增加浓度的组胺来确定每位志愿者的瘙痒阈值。然后在几乎相同的条件下，以相同的时间间隔给志愿者服用研究药物和安慰剂，并再次测定瘙痒阈值。对硫利达嗪、盐酸羟嗪、氯丙嗪、甲硫哒嗪和乳糖安慰剂进行了评估。与其他药物相比，单独使用羟嗪在抑制组胺诱导的瘙痒方面更有效。因此，羟嗪可能对组胺诱导的瘙痒更有效。本研究中使用的抗精神病药物对组胺诱导的瘙痒没有显著抑制作用，但它们可能对非组胺诱导的瘙痒或精神性瘙痒有益。
