从鼠肉瘤病毒转化的仓鼠细胞释放的非感染性病毒样颗粒中病毒核糖核酸依赖性脱氧核糖核酸聚合酶的缺陷
Deficiency of viral ribonucleic acid-dependent deoxyribonucleic acid polymerase in noninfectious virus-like particles released from murine sarcoma virus-transformed hamster cells.
作者信息
Peebles P T, Haapala D K, Gazdar A F
出版信息
J Virol. 1972 Mar;9(3):488-93. doi: 10.1128/JVI.9.3.488-493.1972.
Abstract
Virions from hamster cells transformed by a new strain of murine sarcoma virus (MSV) appear to represent a form of MSV deficient in one or more of the viral components necessary for infectivity. Both the noninfectious virions and the sarcoma virus-transformed cells, which have no detectable replicating leukemia helper virus of either murine or hamster origin, are deficient in viral-type ribonucleic acid (RNA)-dependent deoxyribonucleic acid (DNA) polymerase activity (i.e., reverse transcriptase activity stimulated by the synthetic RNA-DNA template polyribo-adenylic-oligodeoxythymidylic acid). In comparison, both murine leukemia virus (MuLV) and MuLV-infected cells have abundant viral-type reverse transcriptase activity. It appears, therefore, that the leukemia virus genome may be required for the production of infectious sarcoma virus by contributing information needed for the full expression of functional viral-type reverse transcriptase.
摘要
由一种新型鼠肉瘤病毒（MSV）转化的仓鼠细胞产生的病毒粒子似乎代表了MSV的一种形式，这种形式在感染性所需的一种或多种病毒成分上存在缺陷。非感染性病毒粒子和肉瘤病毒转化细胞，均未检测到源自鼠类或仓鼠的可复制白血病辅助病毒，它们都缺乏病毒型核糖核酸（RNA）依赖性脱氧核糖核酸（DNA）聚合酶活性（即由合成的RNA-DNA模板聚核糖腺苷酸-寡聚脱氧胸苷酸刺激的逆转录酶活性）。相比之下，鼠白血病病毒（MuLV）和感染MuLV的细胞都具有丰富的病毒型逆转录酶活性。因此，似乎白血病病毒基因组可能通过提供功能性病毒型逆转录酶充分表达所需的信息，来参与产生感染性肉瘤病毒。
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