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一种非感染性C型病毒诱导肿瘤特异性细胞介导免疫

Induction of tumor-specific cell-mediated immunity by a noninfectious type-C virus.

作者信息

Datta S K, McCormick K J, Trentin J J

出版信息

Infect Immun. 1981 Jul;33(1):126-9. doi: 10.1128/iai.33.1.126-129.1981.

DOI:10.1128/iai.33.1.126-129.1981
PMID:6167517
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC350663/
Abstract

Hamsters immunized with either noninfectious hamster type-C virus (D9) or irradiated D9 tumor cells were tested for cell-mediated immune reactivity by the macrophage migration inhibition assay. The migration of peritoneal exudate cells from immunized hamsters was significantly inhibited by either D9 virus or D9 tumor extract, but not by extract of an unrelated CELO virus-induced tumor. The virus and tumor extracts had little or no effect on the migration of peritoneal exudate cells from normal hamsters. Noninfectious D9 virus produces a cell-mediated immune response in the hamster and shares antigenicity with D9 lymphoma, which releases the virus.

摘要

用非感染性仓鼠C型病毒（D9）或经辐射的D9肿瘤细胞免疫的仓鼠，通过巨噬细胞迁移抑制试验检测其细胞介导的免疫反应性。来自免疫仓鼠的腹腔渗出细胞的迁移受到D9病毒或D9肿瘤提取物的显著抑制，但不受无关的CELO病毒诱导肿瘤的提取物的抑制。病毒和肿瘤提取物对正常仓鼠腹腔渗出细胞的迁移几乎没有影响。非感染性D9病毒在仓鼠中产生细胞介导的免疫反应，并与释放该病毒的D9淋巴瘤具有共同抗原性。

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