Rønningen H, Langeland N
Acta Orthop Scand. 1979 Apr;50(2):169-74. doi: 10.3109/17453677908989752.
The course of osteoarthritis in 294 hips of 186 patients was evaluated by examining their radiographs. The development of the disease in patients treated with indomethacin was compared with that in a control material. In the indomethacin group the disease progressed more frequently and in one parameter the progress was more severe. The results support previous reports indicating that indomethacin might have a deleterious effect on osteoarthritic hip joints. Some possible explanations for this adverse effect of indomethacin treatment are discussed.
通过检查186例患者的294个髋关节的X光片，对骨关节炎的病程进行了评估。将使用消炎痛治疗的患者的疾病发展情况与对照材料中的情况进行了比较。在消炎痛组中，疾病进展更为频繁，且在一个参数上进展更为严重。这些结果支持了先前的报告，表明消炎痛可能对骨关节炎髋关节有有害影响。讨论了消炎痛治疗产生这种不良反应的一些可能解释。
