Jao W, Gould V E
Cancer. 1975 May;35(5):1280-92. doi: 10.1002/1097-0142(197505)35:5<1280::aid-cncr2820350503>3.0.co;2-8.
Three anaplastic (spindle and giant cell) carcinomas of the thyroid were studied by light and electron microscopy; two of the tumors also included foci of recognizable follicular carcinoma. The follicular carcinoma cells desplayed prominent mitochondria and rough endoplasmic reticulum, and showed evidence of secretory activity. Desmosomes and complex cellular interdigitations were evident. Basal laminae were present, with conspicuous reduplication in the well-differentiated foci. However, some epithelial clusters were surrounded by basal lamina, showing focal discontinuities through which epithelial cells protruded into the stroma. The pleomorphic spindle and giant cells showed cytoplasmic and nuclear characteristics similar to the better differentiated carcinomatous follicular elements, but showed rare desmosomes and no basal laminae. The basic ultrastructural similarity between follicular and anaplastic tumor cells confirms their common epithelial origin. However, while partially retaining their secretory capability, the anaplastic cells progressively lose their capacity to synthetize basal lamina and develop complex cellular attachments.
对三例甲状腺间变性（梭形细胞和巨细胞）癌进行了光镜和电镜研究；其中两例肿瘤还包含可识别的滤泡癌灶。滤泡癌细胞显示出突出的线粒体和粗面内质网，并表现出分泌活动的迹象。桥粒和复杂的细胞交错明显。存在基膜，在高分化灶中有明显的重复。然而，一些上皮细胞簇被基膜包围，显示出局部不连续性，上皮细胞通过这些不连续性突入间质。多形性梭形细胞和巨细胞显示出与分化较好的癌性滤泡成分相似的细胞质和细胞核特征，但桥粒罕见且无基膜。滤泡细胞和间变性肿瘤细胞之间基本的超微结构相似性证实了它们共同的上皮起源。然而，间变性细胞在部分保留其分泌能力的同时，逐渐丧失合成基膜和形成复杂细胞连接的能力。
