生物制品在仓鼠中缺乏显著致癌性。
Lack of significant oncogenicity of biological products in hamsters.
作者信息
Cox C B, Landon J, Valerio M G, Palmer A, Kirschstein R L, Singer S H
出版信息
Appl Microbiol. 1972 Apr;23(4):675-8. doi: 10.1128/am.23.4.675-678.1972.
Abstract
A variety of biological products which included live and inactivated viral vaccines, inactivated rickettsial and bacterial vaccines, toxoids, and a multiple bacterial antigen product did not appear to be oncogenic for newborn hamsters following a single subcutaneous inoculation. The incidence of spontaneous tumors was approximately 4.7%, and this figure was not significantly altered by the inoculation of any of the test materials.
摘要
多种生物制品，包括活病毒疫苗和灭活病毒疫苗、灭活立克次体疫苗和细菌疫苗、类毒素以及一种多细菌抗原产品，在新生仓鼠单次皮下接种后似乎不具有致癌性。自发肿瘤的发生率约为4.7%，接种任何一种测试材料均未显著改变这一数字。
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