Hull R N, Johnson I S, Culbertson C G, Reimer C B, Wright H F
Science. 1965 Nov 19;150(3699):1044-6. doi: 10.1126/science.150.3699.1044.
Five of 17 adenoviruses of rhesus or cynomolgus monkey origin induced tumors in newborn hamsters. The tumors appeared between 42 and 280 days after subcutaneous inoculation and had the general characteristics of lymphomas. The tumors were specific by cross-complement fixation tests. An adenovirus recovered from Cercopithecus monkeys appeared to be highly oncogenic; all 23 inoculated hamsters developed tumors within 30 to 40 days.
17种源自恒河猴或食蟹猴的腺病毒中有5种可在新生仓鼠体内诱发肿瘤。肿瘤在皮下接种后42至280天出现,具有淋巴瘤的一般特征。通过交叉补体结合试验,这些肿瘤具有特异性。从猕猴体内分离出的一种腺病毒似乎具有高度致癌性;所有23只接种的仓鼠在30至40天内都长出了肿瘤。