Skaare J U, Nafstad I
Acta Pharmacol Toxicol (Copenh). 1979 Apr;44(4):303-7. doi: 10.1111/j.1600-0773.1979.tb02334.x.
Adult male rats were given the antioxidant 14C-ethoxyquin by oral intubation and were sacrificed at various time intervals from 0.5 hr to 6 days following administration of the drug. The distribution pattern was studied by whole-body autoradiography and liquid scintillation counting. The isotopelabelled antioxidant was distributed throoughout most tissues and the blood at 0.5 hr after administration. The highest radioactivity throughout the experimental period was observed in the liver, the kidney, the gastrointestinal tract and the adipose tissue. No activity was observed in the brain and the central nervous system. Of the dose ingested 2.2 and 0.2% were found in the liver at 0.5 hr and 6 days respectively following dosing. The hepatic peak in radioactivity was measured at 8 hrs and after 6 days 7.5% of this level was still present in the liver. Six days after administration residues of ethoxyquin and metabolites were also present in the kidney cortex, the intestines, the lung, various adipose tissue and blood.
成年雄性大鼠经口插管给予抗氧化剂14C - 乙氧喹，并在给药后0.5小时至6天的不同时间间隔处死。通过全身放射自显影和液体闪烁计数研究其分布模式。给药后0.5小时，同位素标记的抗氧化剂分布于大多数组织和血液中。在整个实验期间，肝脏、肾脏、胃肠道和脂肪组织中的放射性最高。在脑和中枢神经系统中未观察到活性。给药后0.5小时和6天，分别在肝脏中发现摄入剂量的2.2%和0.2%。放射性在肝脏中的峰值在8小时测得，6天后该水平的7.5%仍存在于肝脏中。给药6天后，肾皮质、肠道、肺、各种脂肪组织和血液中也存在乙氧喹及其代谢物的残留。
