大鼠体内抗氧化剂乙氧喹（6-乙氧基-2,2,4-三甲基-1,2-二氢喹啉）的代谢研究

Studies on the metabolism of the antioxidant ethoxyquin, 6-ethoxy-2,2,4-trimethyl-1,2-dihydroquinoline in the rat.

Skaare J U, Solheim E

Xenobiotica. 1979 Nov;9(11):649-57. doi: 10.3109/00498257909042332.

Abstract

The metabolism of ethoxyquin (6-ethoxy-2,2,4-trimethyl-1,2-dihydroquinoline) in rat has been investigated. Urinary metabolites were identified by combined g.l.c.-mass spectrometry. 2. The major metabolic reaction was de-ethylation which gave rise to 6-hydroxy-2,2,4-trimethyl-1,2-dihydroquinoline and an oxidation product, 2,2,4-trimethyl-6-quinolone. Other reactions were hydroxylation to four different hydroxylated metabolites and one dihydroxylated metabolite. A total of 95% of the dose (100 mg/kg) was accounted for.

摘要

已对大鼠体内乙氧喹（6-乙氧基-2,2,4-三甲基-1,2-二氢喹啉）的代谢进行了研究。通过气相色谱-质谱联用对尿液代谢产物进行了鉴定。2. 主要代谢反应是脱乙基反应，生成6-羟基-2,2,4-三甲基-1,2-二氢喹啉和一种氧化产物2,2,4-三甲基-6-喹诺酮。其他反应包括羟基化生成四种不同的羟基化代谢产物和一种二羟基化代谢产物。给药剂量（100mg/kg）的95%得到了说明。