白血病性网状内皮增生症“毛细胞”的超微结构特征

Katayama I, Li C Y, Yam L T

Am J Pathol. 1972 May;67(2):361-70.

The pathognomonic neoplastic reticulum cells, or "hairy cells" of leukemic reticuloendotheliosis from 6 patients were studied with the electron microscope. These cells demonstrated characteristic ultrastructural features which were distinctly different from those of lymphocytes, monocytes, or histiocytes. In 3 patients a distinctive ribosome-lamella complex was found. The biologic significance of this unusual cytoplasmic inclusion is still unknown. Its frequent presence in leukemic reticuloendotheliosis and its rarity in other neoplastic diseases suggest a substantial yet unexplained relationship between this complex and leukemic reticuloendotheliosis.

对6例白血病性网状内皮增生症患者的特征性肿瘤性网状细胞，即“毛细胞”进行了电子显微镜研究。这些细胞呈现出特征性的超微结构特征，与淋巴细胞、单核细胞或组织细胞明显不同。在3例患者中发现了一种独特的核糖体-板层复合体。这种异常胞质内含物的生物学意义尚不清楚。它在白血病性网状内皮增生症中频繁出现，而在其他肿瘤性疾病中罕见，提示该复合体与白血病性网状内皮增生症之间存在一种尚未阐明的重要关系。