Lehner T, Wilton J M, Ivanyi L
Immunology. 1972 May;22(5):775-87.
Cell-mediated and humoral immune responses have been investigated in fifteen patients with chronic muco-cutaneous candidosis and appropriate controls. An impaired cellular response to was found in all patients by the cytotoxicity test, using specifically activated lymphocytes which were reacted against Cr labelled chicken red cells. Migration of guinea-pig macrophages was not inhibited by supernatants from stimulated leucocyte cultures in eleven out of twelve patients and similar results were found when these patients were skin tested for delayed hypersensitivity. A significant though low grade lymphocyte transformation reaction was detected in five patients, two of whom yielded a negative delayed skin reaction. Responses to unrelated antigens, such as PPD and were also impaired in some patients but to a lesser extent than to . It is suggested that chronic muco-cutaneous candidosis shows a spectrum of increasing cell-mediated immunodeficiencies which can be ranked into six grades. Chronic oral candidosis has a limited cellular immune defect (Grades A, B and C) whereas in the muco-cutaneous candidosis a more severe immunodeficiency is found (Grades D, E and F). Serum IgG and IgM antibodies to Candida were largely impaired in all but one grade of immunodeficiency (Grade E), whereas salivary IgA antibodies were deficient in the three more severe grades of immunodeficiencies (D, E and F).
对15例慢性黏膜皮肤念珠菌病患者及适当对照进行了细胞介导免疫和体液免疫反应的研究。通过细胞毒性试验发现，所有患者对[此处原文缺失具体刺激物]的细胞反应均受损，该试验使用经特异性激活的淋巴细胞与铬标记的鸡红细胞反应。12例患者中有11例，豚鼠巨噬细胞的迁移未被刺激的白细胞培养上清液抑制，并且当对这些患者进行迟发型超敏反应皮肤试验时也得到了类似结果。在5例患者中检测到显著但程度较低的淋巴细胞转化反应，其中2例患者的迟发型皮肤反应为阴性。一些患者对诸如PPD和[此处原文缺失具体抗原]等无关抗原的反应也受损，但程度低于对[此处原文缺失具体刺激物]的反应。提示慢性黏膜皮肤念珠菌病表现出一系列逐渐加重的细胞介导免疫缺陷，可分为六个等级。慢性口腔念珠菌病存在有限的细胞免疫缺陷（A、B和C级），而在黏膜皮肤念珠菌病中发现更严重的免疫缺陷（D、E和F级）。除一个免疫缺陷等级（E级）外，所有患者针对念珠菌的血清IgG和IgM抗体在很大程度上受损，而唾液IgA抗体在三个更严重的免疫缺陷等级（D、E和F级）中缺乏。
