慢性伤寒带菌者的体液免疫和细胞介导免疫反应。
Humoral and cell-mediated immune responses in chronic typhoid carriers.
作者信息
Dham S K, Thompson R A
出版信息
Clin Exp Immunol. 1982 Oct;50(1):34-40.
Humoral and cell-mediated immune responses to Salmonella typhi were studied in 10 chronic typhoid carriers, and in healthy controls. Carriers showed impaired cellular reactivity to S. typhi antigens in the leucocyte migration inhibition test (LMI). Carriers did not show a generalized depression of cell-mediated immunity in that delayed hypersensitivity skin test responses to recall antigens, peripheral blood T cell numbers, and lymphocyte transformation responses to mitogens were normal. Lymphocyte transformation in the presence of S. typhi antigen occurred to a greater extent than normal in four of six subjects tested and suggested the possibility of dissociated defects of cellular immunity. Carriers showed normal humoral immunity, as judged by antibodies to the flagellar and somatic antigens of S. typhi and S. paratyphi and to Vi antigens of S. typhi. The results suggest that the carrier state may be the consequence of a specific defect in cell-mediated immune responses to S. typhi.
在10名慢性伤寒带菌者和健康对照者中研究了对伤寒沙门氏菌的体液免疫和细胞介导免疫反应。在白细胞迁移抑制试验（LMI）中，带菌者对伤寒沙门氏菌抗原的细胞反应性受损。带菌者并未表现出细胞介导免疫的普遍抑制，因为对回忆抗原的迟发型超敏皮肤试验反应、外周血T细胞数量以及对有丝分裂原的淋巴细胞转化反应均正常。在测试的6名受试者中有4名，在伤寒沙门氏菌抗原存在的情况下淋巴细胞转化程度高于正常，提示存在细胞免疫分离缺陷的可能性。根据针对伤寒沙门氏菌和副伤寒沙门氏菌鞭毛和菌体抗原以及伤寒沙门氏菌Vi抗原的抗体判断，带菌者的体液免疫正常。结果表明，带菌状态可能是对伤寒沙门氏菌细胞介导免疫反应存在特定缺陷的结果。
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