源自铜绿假单胞菌1822的一种R因子的特性。
Properties of a R factor which originated in Pseudomonas aeruginosa 1822.
作者信息
Grinsted J, Saunders J R, Ingram L C, Sykes R B, Richmond M H
出版信息
J Bacteriol. 1972 May;110(2):529-37. doi: 10.1128/jb.110.2.529-537.1972.
Abstract
RP1, a group of genes specifying resistance to carbenicillin, neomycin, kanamycin, and tetracycline and originating in a strain of Pseudomonas aeruginosa, was freely transmissible between strains of P. aeruginosa, Escherichia coli, and Proteus mirabilis. Acquisition of the multiple drug resistance specified by RP1 by these strains was accompanied by acquisition of an extrachromosomal satellite of covalently closed circular deoxyribonucleic acid of molecular weight about 40 million daltons and of buoyant density 1.719 g/cm(3) (60% guanine plus cytosine).
摘要
RP1是一组指定对羧苄青霉素、新霉素、卡那霉素和四环素具有抗性的基因，起源于一株铜绿假单胞菌，它能在铜绿假单胞菌、大肠杆菌和奇异变形杆菌菌株之间自由传递。这些菌株获得由RP1指定的多重耐药性时，伴随着获得一种分子量约为4000万道尔顿、浮力密度为1.719克/立方厘米（鸟嘌呤加胞嘧啶含量为60%）的共价闭合环状脱氧核糖核酸的染色体外卫星分子。
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