Temin H M
Proc Natl Acad Sci U S A. 1972 Apr;69(4):1016-20. doi: 10.1073/pnas.69.4.1016.
The members of the RNA tumor virus (or leukovirus) group of animal viruses replicate via a DNA intermediate and transmit their information stably in cells as DNA. Although some of these viruses are capable of inducing neoplastic transformation, others are not. These viruses may be related to spontaneous neoplasia, but the relationship is that of analogy rather than etiology. The relationship of these viruses to human disease is unknown. Two models of spontaneous neoplasia that involve either activation of the information of a transforming RNA tumor virus or the creation of information for neoplastic transformation by recombination involving information transfer from RNA to DNA are being tested in model systems.
动物病毒中的RNA肿瘤病毒（或白血病病毒）组的成员通过DNA中间体进行复制，并以DNA的形式在细胞中稳定传递其信息。虽然这些病毒中的一些能够诱导肿瘤转化，但其他的则不能。这些病毒可能与自发性肿瘤形成有关，但这种关系是类比关系而非病因关系。这些病毒与人类疾病的关系尚不清楚。涉及转化RNA肿瘤病毒信息激活或通过涉及从RNA到DNA信息转移的重组产生肿瘤转化信息的两种自发性肿瘤形成模型正在模型系统中进行测试。
