在禽细胞DNA中检测禽肿瘤病毒特异性核苷酸序列（重缔合动力学- RNA肿瘤病毒-气体抗原-劳氏肉瘤病毒，鸡细胞）
Detection of avian tumor virus-specific nucleotide sequences in avian cell DNAs (reassociation kinetics-RNA tumor viruses-gas antigen-Rous sarcoma virus, chick cells).
作者信息
Varmus H E, Weiss R A, Friis R R, Levinson W, Bishop J M
出版信息
Proc Natl Acad Sci U S A. 1972 Jan;69(1):20-4. doi: 10.1073/pnas.69.1.20.
Abstract
The effect of unlabeled cellular DNA upon the reassociation kinetics of labeled double-stranded DNA made by DNA polymerase from avian tumor viruses has been used to measure virus-specific nucleotide sequences in cells. Multiple copies of these sequences were found equally in normal chick cells, in chick cells transformed in culture, and in Rous tumor cells. Copies were also present equally in cells harboring chick helper factor and group-specific antigen, and in cells lacking those characteristics. Quail DNA also contains multiple copies of these sequences, but no copies were detected in HeLa-cell DNA or salmon-sperm DNA.
摘要
未标记的细胞DNA对禽肿瘤病毒DNA聚合酶合成的标记双链DNA重缔合动力学的影响已被用于测量细胞中的病毒特异性核苷酸序列。在正常鸡细胞、培养中转化的鸡细胞和劳氏肿瘤细胞中均发现了这些序列的多个拷贝。在含有鸡辅助因子和群特异性抗原的细胞以及缺乏这些特征的细胞中，拷贝数也相同。鹌鹑DNA也含有这些序列的多个拷贝，但在HeLa细胞DNA或鲑鱼精子DNA中未检测到拷贝。
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Detection of avian tumor virus-specific nucleotide sequences in avian cell DNAs (reassociation kinetics-RNA tumor viruses-gas antigen-Rous sarcoma virus, chick cells).在禽细胞DNA中检测禽肿瘤病毒特异性核苷酸序列（重缔合动力学- RNA肿瘤病毒-气体抗原-劳氏肉瘤病毒，鸡细胞）
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本文引用的文献
1
ISOLATION OF HIGH MOLECULAR WEIGHT DNA FROM HEMOPHILUS INFLUENZAE.从流感嗜血杆菌中分离高分子量DNA。
J Mol Biol. 1965 Mar;11:476-90. doi: 10.1016/s0022-2836(65)80004-3.
2
HOMOLOGY BETWEEN RNA FROM ROUS SARCOMA VIROUS AND DNA FROM ROUS SARCOMA VIRUS-INFECTED CELLS.劳氏肉瘤病毒的RNA与劳氏肉瘤病毒感染细胞的DNA之间的同源性。
Proc Natl Acad Sci U S A. 1964 Aug;52(2):323-9. doi: 10.1073/pnas.52.2.323.
3
THE EFFECTS OF ACTINOMYCIN D ON GROWTH OF ROUS SARCOMA VIRUS IN VITRO.放线菌素D对劳氏肉瘤病毒体外生长的影响。
Virology. 1963 Aug;20:577-82. doi: 10.1016/0042-6822(63)90282-4.
4
Kinetics of renaturation of DNA.DNA复性动力学
J Mol Biol. 1968 Feb 14;31(3):349-70. doi: 10.1016/0022-2836(68)90414-2.
5
Oncogenes of RNA tumor viruses as determinants of cancer.作为癌症决定因素的RNA肿瘤病毒癌基因。
Proc Natl Acad Sci U S A. 1969 Nov;64(3):1087-94. doi: 10.1073/pnas.64.3.1087.
6
An avian leukosis virus related to RSV(O): properties and evidence for helper activity.一种与劳斯肉瘤病毒（O型）相关的禽白血病病毒：特性及辅助活性证据
Virology. 1971 Jan;43(1):223-34. doi: 10.1016/0042-6822(71)90240-6.
7
Repeated sequences in DNA. Hundreds of thousands of copies of DNA sequences have been incorporated into the genomes of higher organisms.DNA中的重复序列。数以十万计的DNA序列拷贝已被纳入高等生物的基因组中。
Science. 1968 Aug 9;161(3841):529-40. doi: 10.1126/science.161.3841.529.
8
DNA in uninfected and virus-infected cells complementary to avian tumor virus RNA.未感染和病毒感染细胞中与禽肿瘤病毒RNA互补的DNA。
Proc Natl Acad Sci U S A. 1971 Oct;68(10):2336-40. doi: 10.1073/pnas.68.10.2336.
9
Deoxyribonucleic acid polymerases of Rous sarcoma virus: kinetics of deoxyribonucleic acid synthesis and specificity of the products.劳氏肉瘤病毒的脱氧核糖核酸聚合酶：脱氧核糖核酸合成动力学及产物特异性
J Virol. 1971 Feb;7(2):227-32. doi: 10.1128/JVI.7.2.227-232.1971.
10
Extent of transcription by the RNA-dependent DNA polymerase of Rous sarcoma virus.劳氏肉瘤病毒的RNA依赖性DNA聚合酶的转录范围。
Nat New Biol. 1971 Sep 1;233(35):19-21. doi: 10.1038/newbio233019a0.
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