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Apparent dose-dependent absorption of chlorothiazide in dogs.

作者信息

Resetarits D E, Bates T R

出版信息

J Pharmacokinet Biopharm. 1979 Oct;7(5):463-70. doi: 10.1007/BF01062388.

DOI:10.1007/BF01062388
PMID:43383
Abstract

The purpose of this study was to determine the effect of oral dose on the absorption of chlorothiazide in the dog. Chlorothiazide was quantitatively excreted in the urine after administration of 50-mg and 250-mg intravenous doses. In contrast, the urinary recovery of chlorothiazide after oral administration showed appreciable interanimal variation and decreased from 70.4% to 26.7% on the average as the oral dose was increased from 125 mg to 750 mg. Oral administration of a single 15-mg dose of propantheline bromide (a potent inhibitor of gastric emptying and intestinal motility) at--1 hr increased the absorption of a 250 mg oral dose of chlorothiazide in three out of four dogs. These results suggest that chlorothiazide absorption is dose dependent and apparently site specific.

摘要

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本文引用的文献

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Enhancement of the gastrointestinal absorption of hydrochlorothiazide by propantheline.丙胺太林增强氢氯噻嗪的胃肠道吸收。
Eur J Clin Pharmacol. 1978 Jul 30;13(5):385-7. doi: 10.1007/BF00644613.
8
Gastrointestinal absorption of hydrochlorothiazide enhanced by concomitant intake of food.同时摄入食物可增强氢氯噻嗪的胃肠道吸收。
Eur J Clin Pharmacol. 1978 May 17;13(2):125-8. doi: 10.1007/BF00609756.
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Pharmacokinetics of hydrochlorothiazide in man.氢氯噻嗪在人体中的药代动力学。
Eur J Clin Pharmacol. 1977 Dec 2;12(4):297-303. doi: 10.1007/BF00607430.
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Bioavailability of two hydrochlorothiazide preparations.两种氢氯噻嗪制剂的生物利用度。
Eur J Clin Pharmacol. 1977 Mar 11;11(3):203-5. doi: 10.1007/BF00606411.